Metabonomic Evaluation of ZHENG Differentiation and Treatment by Fuzhenghuayu Tablet in Hepatitis-B-Caused Cirrhosis.
Metabonomic Evaluation of ZHENG Differentiation and Treatment by Fuzhenghuayu Tablet in Hepatitis-B-Caused Cirrhosis.
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DOI：
10.1155/2012/453503
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发表时间：
2012
期刊：
影响因子：
--
通讯作者：
Zhang Y
中科院分区：
文献类型：
--
作者：
Sun S;Dai J;Wang W;Cao H;Fang J;Hu YY;Su S;Zhang Y
中医辨证论治已有三千多年的历史，但在与西医的交流中存在一定的困难。本研究应用代谢组学方法对乙型肝炎肝硬化证型进行鉴别，并评价扶正化瘀片对乙型肝炎肝硬化的疗效。采用气相色谱-质谱联用（GC/MS）和多元统计分析方法，对12例健康志愿者（对照组）和31例乙型肝炎患者（HBCG）的尿样进行分析。通过PLS-DA负荷图分析，筛选出CG和HBCG之间差异显著的代谢产物。4个证型之间存在相互分化，提示证型分化存在尿代谢物质基础。FZHY片对脾虚湿阻证和肝肾阴虚证的疗效优于其他证型。扶正化瘀方在辨证论治基础上的疗效表明，准确辨证可指导中医辨证论治。
In Traditional Chinese Medicine (TCM), treatment based on ZHENG (also called TCM syndrome and pattern) differentiation has been applied for about 3 thousand years, while there are some difficulties to communicate with western medicine. In the present work, metabonomic methods were utilized to differentiate ZHENG types and evaluate the therapeutic efficiency of Fuzhenghuayu (FZHY) tablet in hepatitis-B-caused cirrhosis (HBC). Urine samples of 12 healthy volunteers (control group, CG) and 31 HBC patients (HBCG) were analyzed by gas chromatography mass spectrometry (GC/MS) and multivariate statistical analysis. The significantly changed metabolites between CG and HBCG were selected by PLS-DA loading plot analysis. Moreover, 4 ZHENGs were differentiated mutually, suggesting that there was urine metabolic material basis in ZHENG differentiation. The efficiency of FZHY tablet on subjects with spleen deficiency with dampness encumbrance syndrome (SDDES) and liver-kidney yin deficiency syndrome (LKYDS) was better than that of other syndromes. The efficiency of FZHY treatment based on ZHENG differentiation indicated that accurately ZHENG differentiating could guide the appropriate TCM treatment in HBC.
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