New Lives Given by Cell Death: Macrophage Differentiation Following Their Encounter with Apoptotic Leukocytes during the Resolution of Inflammation.
New Lives Given by Cell Death: Macrophage Differentiation Following Their Encounter with Apoptotic Leukocytes during the Resolution of Inflammation.
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DOI：
10.3389/fimmu.2012.00004
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发表时间：
2012
影响因子：
7.3
通讯作者：
Serhan CN
中科院分区：
文献类型：
--
作者：
Ariel A;Serhan CN
在炎症过程中迁移到组织中并分化为巨噬细胞的单核细胞以前被归类为经典(M1)或交替(M2)激活的巨噬细胞，这是基于它们对不同命运决定介质的暴露。这些巨噬细胞亚群表现出不同的分子标记和不同的功能。同时，近年来的研究发现，凋亡的白细胞与巨噬细胞相遇，导致巨噬细胞清除这种细胞碎片，同时伴随着对巨噬细胞的重新编程/免疫沉默。虽然一些M2分化的特征，如精氨酸酶-1(小鼠)和15-脂氧合酶(人和小鼠)的表达，也显示在吞噬凋亡细胞的巨噬细胞中，但尚不清楚凋亡细胞是否可被视为M2样分化信号。在这篇手稿中，我们回顾了最近关于凋亡细胞对巨噬细胞表型改变的影响的分子方面的信息。我们将集中于最近的证据表明，体内存在独特的支持分解的巨噬细胞，以及凋亡细胞、特殊的脂质介质和糖皮质激素在其生成中的作用。因此，我们认为这些前分解CD11bllow巨噬细胞已经从M2样巨噬细胞变性，并调节了它们的蛋白质谱以适应其功能的变化。
Monocytes that migrate into tissues during inflammatory episodes and differentiate to macrophages were previously classified as classically (M1) or alternatively (M2) activated macrophages, based on their exposure to different fate-determining mediators. These macrophage subsets display distinct molecular markers and differential functions. At the same time, studies from recent years found that the encounter of apoptotic leukocytes with macrophages leads to the clearance of this cellular “debris” by the macrophages, while concomitantly reprogramming/immune-silencing the macrophages. While some of the features of M2 differentiation, such as arginase-1 (murine) and 15-lipoxygenases (human and murine) expression, were also displayed by macrophages following the engulfment of apoptotic cells, it was not clear whether apoptotic cells can be regarded as an M2-like differentiating signal. In this manuscript we review the recent information regarding the impact of apoptotic cells on macrophage phenotype changes in molecular terms. We will focus on recent evidence for the in vivo existence of distinct pro-resolving macrophages and the role of apoptotic cells, specialized lipid mediators, and glucocorticoids in their generation. Consequently, we will suggest that these pro-resolving CD11blow macrophages have metamorphed from M2-like macrophages, and modulated their protein profile to accommodate the changes in their function.
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