Early exposure to haloperidol or olanzapine induces long-term alterations of dendritic form.
Early exposure to haloperidol or olanzapine induces long-term alterations of dendritic form.
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DOI：
10.1002/syn.20715
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发表时间：
2010-03
期刊：
影响因子：
2.3
通讯作者：
Kolb, Bryan
中科院分区：
文献类型：
--
作者：
Frost, Douglas O.;Page, Stephanie Cerceo;Carroll, Cathy;Kolb, Bryan
发育中的大脑暴露于各种滥用药物（例如，兴奋剂、阿片类药物、乙醇等）可以导致行为和神经回路的终身变化。然而，接触治疗性精神药物的长期影响直到最近才开始受到重视。抗精神病药物在这方面的研究很少。在这里，我们定量分析了树突状结构的典型（氟哌啶醇）或非典型（奥氮平）抗精神病药物治疗的成年小鼠在发育阶段对应于胎儿或胎儿加人类幼儿期。在第3层锥体细胞的内侧和眶前额叶皮质和顶叶皮质和多刺神经元的核心的核神经元，这两种药物诱导显着的变化（主要是减少）的数量和复杂性的树突乔木和密度的树突棘。药物诱导的树突状结构的可塑性表明，在多个大脑区域的神经元连接模式的变化，可能是功能上显着的。
Exposure of the developing brain to a wide variety of drugs of abuse (eg., stimulants, opioids, ethanol, etc.) can induce life-long changes in behavior and neural circuitry. However, the long-term effects of exposure to therapeutic, psychotropic drugs have only recently begun to be appreciated. Antipsychotic drugs are little studied in this regard. Here we quantitatively analyzed dendritic architecture in adult mice treated with paradigmatic typical- (haloperidol) or atypical (olanzapine) antipsychotic drugs at developmental stages corresponding to fetal or fetal plus early childhood stages in humans. In layer 3 pyramidal cells of the medial and orbital prefrontal cortices and the parietal cortex and in spiny neurons of the core of the nucleus accumbens, both drugs induced significant changes (predominantly reductions) in the amount and complexity of dendritic arbor and the density of dendritic spines. The drug-induced plasticity of dendritic architecture suggests changes in patterns of neuronal connectivity in multiple brain regions that are likely to be functionally significant.
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