A Study of Nerve Regeneration Across Synthetic (Maxon) and Biologic (Collagen) Nerve Conduits For Nerve Gaps Up to 5 Cm in the Primate
A Study of Nerve Regeneration Across Synthetic (Maxon) and Biologic (Collagen) Nerve Conduits For Nerve Gaps Up to 5 Cm in the Primate
复制标题
针对灵长类动物神经间隙高达 5 厘米的合成 (Maxon) 和生物（胶原）神经导管的神经再生研究
DOI：
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发表时间：
1990
影响因子：
2.1
通讯作者：
A. Dellon
中科院分区：
文献类型：
--
作者：
S. Mackinnon;A. Dellon
在灵长类动物模型中，使用合成神经导管（乙交酯三亚甲基碳酸酯，Maxon）和生物导管（胶原）对 2 厘米和 5 厘米神经间隙的神经再生进行了评估。对两种类型的乙交酯三亚甲基碳酸酯 (Maxon) 导管进行了评估。第一个是用一块扁平的 Maxon 网格制成管子。第二个是以卷曲形式预制的。评估的另一种材料是生物胶原蛋白管。 14 个月时，通过胶原蛋白和 Maxon 导管，2 厘米的神经间隙出现了良好的再生。在 5 cm 处，通过形态分析确定，Maxon 预制卷曲导管的再生明显更好，尽管所有实验组中较长间隙的再生明显低于较短神经间隙的再生。在较长的间隙中，通过电生理学评估，各组之间没有统计学差异。
In a primate model, nerve regeneration was evaluated across 2- and 5-cm nerve gaps using a synthetic nerve conduit (glycolide trimethylene carbonate, Maxon) and a biologic conduit (collagen). Two types of conduits from glycolide trimethylene carbonate (Maxon) were evaluated. The first was fashioned into a tube from a single flat piece of Maxon mesh. The second was prefabricated in a crimped form. The other material evaluated was a biologic collagen tube. At 14 months, excellent regeneration was noted across the 2-cm nerve gap through both the collagen and Maxon conduits. At 5 cm, the regeneration, as determined by morphometric analysis, was significantly better across the Maxon prefabricated, crimped conduit, although regeneration at this longer gap in all experimental groups was significantly less than across the shorter nerve gap. At the longer gap, there was no statistical difference between the groups by electrophysiologic assessment.
影响因子：
2.7
作者：
ROGERS, SL;LETOURNEAU, PC;FURCHT, LT
通讯作者：
FURCHT, LT