Biological consequences of cancer radiotherapy in the context of oral squamous cell carcinoma.
Biological consequences of cancer radiotherapy in the context of oral squamous cell carcinoma.
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DOI：
10.1186/s13005-021-00286-y
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发表时间：
2021-08-26
影响因子：
3
通讯作者：
Feller L
中科院分区：
文献类型：
--
作者：
Feller G;Khammissa RAG;Nemutandani MS;Feller L
大约50%的癌症受试者在其疾病的临床过程中的某个时间点接受了电离辐射（IR）治疗，无论是作为治愈剂、辅助剂、新辅助剂还是作为姑息剂。IR通过损伤癌细胞的DNA直接杀死癌细胞，并通过诱导由细胞毒性T细胞介导的免疫原性细胞杀伤间接杀死癌细胞;但它也可以诱导对未照射的邻近细胞（旁观者效应）和对照射的原发肿瘤区域外的更远距离细胞（远距离效应）的有害生物反应。虽然IR可以上调抗肿瘤免疫反应，但它也可以促进免疫抑制肿瘤微环境。因此，放疗本身很少足以产生有效的持久免疫应答，能够控制转移的生长、原发性肿瘤的复发和第二原发性癌症的发展。因此，将放射治疗与免疫佐剂如免疫检查点抑制剂的使用相结合，可以增强IR介导的抗肿瘤免疫反应，从而产生协同的免疫原性细胞杀伤作用。本叙述性综述的目的是讨论IR诱导的生物学反应的某些方面，包括有助于肿瘤放射敏感性/放射抗性、免疫原性细胞杀伤和远位效应的因素。
Approximately 50% of subjects with cancer have been treated with ionizing radiation (IR) either as a curative, adjuvant, neoadjuvant or as a palliative agent, at some point during the clinical course of their disease. IR kills cancer cells directly by injuring their DNA, and indirectly by inducing immunogenic cell killing mediated by cytotoxic T cells; but it can also induce harmful biological responses to non-irradiated neighbouring cells (bystander effect) and to more distant cells (abscopal effect) outside the primary tumour field of irradiation. Although IR can upregulate anti-tumour immune reactions, it can also promote an immunosuppressive tumour microenvironment. Consequently, radiotherapy by itself is seldom sufficient to generate an effective long lasting immune response that is capable to control growth of metastasis, recurrence of primary tumours and development of second primary cancers. Therefore, combining radiotherapy with the use of immunoadjuvants such as immune checkpoint inhibitors, can potentiate IR-mediated anti-tumour immune reactions, bringing about a synergic immunogenic cell killing effect. The purpose of this narrative review is to discuss some aspects of IR-induced biological responses, including factors that contributes to tumour radiosensitivity/radioresistance, immunogenic cell killing, and the abscopal effect.
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影响因子：
3
作者：
Feller L;Khammissa RAG;Kramer B;Altini M;Lemmer J
通讯作者：
Lemmer J
治疗改善和更好的患者护理：哪个是口腔癌中最重要的？
DOI：
10.1186/s13014-014-0263-x
发表时间：
2014-11-27
期刊：
Radiation oncology (London, England)
影响因子：
--
作者：
De Felice F;Musio D;Terenzi V;Valentini V;Cassoni A;Tombolini M;De Vincentiis M;Tombolini V
通讯作者：
Tombolini V
影响因子：
4.7
作者：
Demaria S;Formenti SC
通讯作者：
Formenti SC
影响因子：
4.7
作者：
Demaria S;Formenti SC
通讯作者：
Formenti SC
成纤维细胞和癌细胞的同时辐照抑制能够刺激癌细胞迁移的可溶性因子的分泌。
影响因子：
3.7
作者：
Arshad A;Deutsch E;Vozenin MC
通讯作者：
Vozenin MC