Effect of volatile anesthetic agents on endothelium-dependent relaxation.
Effect of volatile anesthetic agents on endothelium-dependent relaxation.
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挥发性麻醉剂对内皮依赖性松弛的影响。
DOI：
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发表时间：
1991
影响因子：
--
通讯作者：
G. Blaise
中科院分区：
文献类型：
--
作者：
G. Blaise
挥发性麻醉药的血管扩张机制是复杂的，尚未完全了解。已知内皮控制平滑肌张力以及其对大多数血管活性物质的反应。内皮不仅代谢血管活性物质，而且分泌多种血管舒张剂（前列环素、EDRF、超极化因子）和血管收缩剂（内皮素、EDCF）。1在过去几年中，怀疑挥发性麻醉剂对内皮依赖性血管舒张的影响。Blaise等人2已经证明异氟烷对离体犬冠状动脉环对5-羟色胺和前列腺素F2 α的收缩反应的衰减依赖于内皮的存在。由于用吲哚美辛预处理血管环仅略微降低了这种衰减，因此推测异氟烷的作用是通过EDRF释放或作用介导的。Muldoon等人3已经表明氟烷降低了预收缩的兔和犬血管环对乙酰胆碱和缓激肽的反应。这表明氟烷抑制EDRF的释放或作用。我们的研究结果是相似的，并且表明，与异氟烷相反，氟烷减弱了裸露血管（无内皮）中离体犬冠状动脉环的肾上腺素能反应，但在完整血管中则不然。4这些初步研究结果表明，异氟烷对内皮依赖性扩张存在积极的相互作用，氟烷则存在消极的相互作用。最近，Stone等人5证明挥发性药物对离体预收缩大鼠主动脉的张力具有双相、剂量依赖性作用。在较低剂量下，张力增加;在较高剂量下，等长力降低。挥发性药物引起的张力增加仅发生在有内皮的血管中，并且消炎痛明显增强。这些数据还表明，这些药物影响内皮功能和前列腺素合成。
The vasodilatory mechanism of volatile anesthetic agents is complex and not yet fully understood. It is known that the endothelium controls smooth muscle tone as well as its response to most vasoactive substances. The endothelium not only metabolizes vasoactive agents, but it secretes several vasodilators (prostacyclin, EDRF, hyperpolarizing factor) and vasoconstrictors (endothelin, EDCF).1 In the last few years, an effect of volatile anesthetic agents on endothelium-dependent vasodilation has been suspected. Blaise et al. 2 have shown that isoflurane’s attenuation of the contractile response of isolated canine coronary artery rings to 5-hydroxytryptamine and prostaglandin F2α was dependent on the presence of the endothelium. As this attenuation was only slightly reduced by pretreatment of the vascular rings with indomethacin, it was postulated that isoflurane’s effect was mediated through EDRF release or action. Muldoon et al. 3 have shown that halothane reduces the response of precontracted rabbit and canine vascular rings to acetylcholine and bradykinin. They suggest that halothane inhibits the release or the action of EDRF. Our findings were similar and showed that, contrary to isoflurane, halothane attenuates the serotoninergic response of isolated canine coronary artery rings in denuded vessels (without endothelium), but not in intact vessels.4 These preliminary findings suggest a positive interaction of isoflurane and a negative interaction of halothane on endothelium-dependent dilation. Recently, Stone et al. 5 have demonstrated that volatile agents have a biphasic, dose-dependent effect on tension of isolated, preconstricted rat aorta. At lower doses, the tension increased; at higher doses, the isometric force decreased. The increase in tension induced by the volatile agents occured only in vessels with endothelium and was clearly potentiated by indomethacin. These data also suggest that these agents affect endothelium function and prostaglandin synthesis.
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钙在动脉平滑肌内皮依赖性松弛中的作用。
DOI：
10.1016/0002-9149(87)90174-3
发表时间：
1987
期刊：
The American journal of cardiology
影响因子：
--
作者：
Peach,MJ;Singer,HA;IzzoJr,NJ;Loeb,AL
通讯作者：
Loeb,AL
血管内皮和 Ca2 拮抗剂。
影响因子：
3
作者：
Vanhoutte,PM
通讯作者：
Vanhoutte,PM
氟烷、安氟烷和异氟烷对离体大鼠主动脉血管环的内皮依赖性影响。
影响因子：
8.8
作者：
Stone,DJ;Johns,RA
通讯作者：
Johns,RA
犬动脉释放两种不同的内皮源性舒张因子。
DOI：
10.1152/ajpheart.1989.257.1.h330
发表时间：
1989
期刊：
The American journal of physiology
影响因子：
--
作者：
Hoeffner,U;Feletou,M;Flavahan,NA;Vanhoutte,PM
通讯作者：
Vanhoutte,PM
一氧化氮、乙酰胆碱以及犬动脉平滑肌的电学和机械特性。
DOI：
10.1152/ajpheart.1988.255.1.h207
发表时间：
1988
期刊：
The American journal of physiology
影响因子：
--
作者：
Komori,K;Lorenz,RR;Vanhoutte,PM
通讯作者：
Vanhoutte,PM