Association between cardiac autonomic nervous dysfunction and the severity of coronary lesions in patients with stable coronary artery disease.
Association between cardiac autonomic nervous dysfunction and the severity of coronary lesions in patients with stable coronary artery disease.
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DOI：
10.1177/0300060518778416
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发表时间：
2018-09
期刊：
影响因子：
--
通讯作者：
Gu Y
中科院分区：
文献类型：
--
作者：
Chen Y;Yu Y;Zou W;Zhang M;Wang Y;Gu Y
自主神经功能障碍在冠状动脉疾病(CAD)患者中被公认，并与较差的心血管结局相关。本研究旨在通过心率恢复率(HRR)和心率变异性(HRV)评价冠心病患者心脏自主神经功能，并探讨其与冠脉病变严重程度的关系。连续的非冠心病患者(对照组，n = 65例)和慢性阻塞性肺疾病患者(n = 63例)纳入本研究。将SCAD患者进一步分为单支或双支/三支病变，以及70%或≥70%狭窄亚组。分析HRR/HRV与冠状动脉病变的关系。SCAD组的心率变异性和心率变异性明显低于对照组。多因素Logistic回归分析显示，心率变异性和心率变异性异常是SCAD的危险因素。此外，延迟的HRR是冠状动脉病变严重程度的危险因素。结果表明，SCAD患者自主神经功能受损，HRR延迟与冠脉病变严重程度密切相关。
Autonomic dysfunction is recognized in patients with coronary artery disease (CAD) and is related to worse cardiovascular outcome. This study aimed to evaluate cardiac autonomic nervous function by heart rate recovery (HRR) and heart rate variability (HRV), and demonstrate their relationship with the severity of coronary lesions in patients with stable CAD (SCAD). Consecutive patients without CAD (controls, n = 65) and those with SCAD (n = 63) were included in this study. Patients with SCAD were further divided into single- or two-/three-vessel disease, as well as <70% or ≥70% stenosis subgroups. The association between HRR/HRV and coronary lesions was analysed. HRR and HRV values were significantly lower in the SCAD group compared with the control group. Multivariate logistic regression analysis showed that abnormal HRR and HRV were risk factors of SCAD. Moreover, delayed HRR was a risk factor of the severity of coronary lesions. Our results show that autonomic function is impaired in patients with SCAD and delayed HRR is closely related to the severity of coronary lesions.
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DOI：
10.1111/j.1520-037x.2007.07310.x
发表时间：
2008-01-01
期刊：
Preventive cardiology
影响因子：
--
作者：
Karnik, Rahool S;Lewis, William;Baker, Larry
通讯作者：
Baker, Larry
影响因子：
168.9
作者：
Al-Lamee, Rasha;Thompson, David;Francis, Darrel P.
通讯作者：
Francis, Darrel P.
影响因子：
1.3
作者：
Akyuz, Aydin;Alpsoy, Seref;Guler, Niyazi
通讯作者：
Guler, Niyazi
影响因子：
6
作者：
Gharacholou, S. Michael;Scott, Christopher G.;Borlaug, Barry A.;Kane, Garvan C.;McCully, Robert B.;Oh, Jae K.;Pellikka, Patricia A.
通讯作者：
Pellikka, Patricia A.
影响因子：
5.7
作者：
Kotecha, D.;New, G.;Krum, H.
通讯作者：
Krum, H.