The promise of human embryonic stem cells in aging-associated diseases.
The promise of human embryonic stem cells in aging-associated diseases.
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DOI：
10.18632/aging.100328
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发表时间：
2011-05
期刊：
影响因子：
--
通讯作者：
Bernstein HS
中科院分区：
文献类型：
--
作者：
Yabut O;Bernstein HS
衰老相关疾病通常是由细胞的进行性损失或功能障碍引起的，最终影响组织和器官的整体功能。这些疾病的成功治疗可以受益于基于细胞的治疗，这种治疗可以再生丢失的细胞或以其他方式恢复组织功能。人胚胎干细胞（human embryonic stem cells，hESC）具有自我更新和多能性的独特能力，有望成为治疗衰老相关疾病的重要候选细胞。迄今为止，已经开发和表征了许多hESC系。我们将讨论hESC系是如何衍生的，它们的分子和细胞特性，以及它们分化成所有三个胚层的能力是如何确定的。我们还将概述目前采用的方法，以指导其分化为组织特异性，功能性细胞的群体。最后，我们将强调必须克服的一般挑战和正在开发的策略，以产生高度纯化的hESC衍生的细胞群，可以安全地用于临床应用。
Aging-associated diseases are often caused by progressive loss or dysfunction of cells that ultimately affect the overall function of tissues and organs. Successful treatment of these diseases could benefit from cell-based therapy that would regenerate lost cells or otherwise restore tissue function. Human embryonic stem cells (hESCs) promise to be an important therapeutic candidate in treating aging-associated diseases due to their unique capacity for self-renewal and pluripotency. To date, there are numerous hESC lines that have been developed and characterized. We will discuss how hESC lines are derived, their molecular and cellular properties, and how their ability to differentiate into all three embryonic germ layers is determined. We will also outline the methods currently employed to direct their differentiation into populations of tissue-specific, functional cells. Finally, we will highlight the general challenges that must be overcome and the strategies being developed to generate highly-purified hESC-derived cell populations that can safely be used for clinical applications.
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