SARS-CoV-2 respiratory co-infections: Incidence of viral and bacterial co-pathogens.
SARS-CoV-2 respiratory co-infections: Incidence of viral and bacterial co-pathogens.
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DOI：
10.1016/j.ijid.2021.02.087
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发表时间：
2021-04
期刊：
影响因子：
--
通讯作者：
Granger J
中科院分区：
文献类型：
--
作者：
Singh V;Upadhyay P;Reddy J;Granger J
由严重急性呼吸系统综合征冠状病毒2型（SARS-CoV-2）引起的2019年全球冠状病毒病（COVID-19）大流行，对我们的医疗保健系统造成了前所未有的挑战。其他病毒性呼吸道病原体的继发性和并发性细菌和病毒合并感染已有充分记录;然而，关于COVID-19合并感染的知识仍然有限。在本研究中，于2020年3月至8月期间对50419份个体样本进行了SARS-CoV-2和其他细菌和病毒呼吸道病原体的同步检测。总体而言，与病毒检测阴性的人群相比，在SARS-CoV-2阳性人群中观察到的病毒合并感染率较低。在SARS-CoV-2阳性人群中检测到显著水平的金黄色葡萄球菌和EB病毒合并感染。这是对美国SARS-CoV-2感染合并感染模式的最大调查之一。这项研究的数据将增强我们对当前流行病的理解，并将帮助临床医生做出更好的患者护理决策，特别是在抗菌治疗方面。
The global coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has resulted in an unprecedented challenge to our healthcare system. Secondary and concurrent bacterial and viral co-infections are well documented for other viral respiratory pathogens; however knowledge regarding co-infections in COVID-19 remains limited. In the present study, concurrent testing of 50 419 individual samples for the presence of SARS-CoV-2 and other bacterial and viral respiratory pathogens was performed between March and August 2020. Overall, a lower rate of viral co-infection was observed in the SARS-CoV-2-positive population when compared to the population testing negative for the virus. Significant levels of Staphylococcus aureus and Epstein–Barr virus co-infections were detected in the SARS-CoV-2-positive population. This is one of the largest surveys looking into the co-infection patterns of SARS-CoV-2 infection in the United States. Data from this study will enhance our understanding of the current pandemic and will assist clinicians in making better patient care decisions, especially with respect to antimicrobial therapy.
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