Ursodeoxycholic acid as a potential alternative therapeutic approach for neurodegenerative disorders: Effects on cell apoptosis, oxidative stress and inflammation in the brain.
Ursodeoxycholic acid as a potential alternative therapeutic approach for neurodegenerative disorders: Effects on cell apoptosis, oxidative stress and inflammation in the brain.
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DOI：
10.1016/j.bbih.2021.100348
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发表时间：
2021-12
期刊：
影响因子：
--
通讯作者：
Huang F
中科院分区：
文献类型：
--
作者：
Huang F
熊去氧胆酸（UDCA）是一种具有抗凋亡、抗氧化和抗炎特性的胆汁酸成分。几个世纪以来，它一直被用于肝脏疾病的临床医学。在神经退行性疾病中，也经常观察到细胞凋亡、氧化应激和炎症的增加。由于UDCA的这些有益作用，最近的研究开始调查UDCA在神经变性临床前模型中的作用。因此，我回顾了迄今为止报道的数据，研究UDCA在神经变性临床前模型以及稳态模型中调节细胞凋亡、氧化应激和炎症的作用。有证据表明，UDCA可以减少神经退行性模型的细胞凋亡，抑制活性氧和肿瘤坏死因子- α的产生。此外，UDCA能够在稳态条件下诱导脑母细胞瘤细胞凋亡。总之，本综述提示UDCA在神经退行性疾病中的治疗潜力，提出UDCA作为这些疾病患者的潜在替代治疗方法。
Ursodeoxycholic acid (UDCA) is a bile acid component with anti-apoptotic, anti-oxidant and anti-inflammatory properties. It has been used in clinical medicine for liver diseases for centuries. In neurodegenerative diseases, increased cell apoptosis, oxidative stress and inflammation are frequently observed as well. Due to those beneficial effects of UDCA, recent studies have started to investigate the effects of UDCA in pre-clinical models of neurodegeneration. On this account, I review the data reported so far to investigate the role of UDCA in regulating apoptosis, oxidative stress and inflammation in pre-clinical models of neurodegeneration, as well as in homeostatic state. Evidence have shown that UDCA can reduce apoptosis, inhibit reactive oxygen species and tumor necrosis factor - α production in neurodegenerative models. In addition, UDCA is able to induce apoptosis of brain blastoma cells in homeostatic conditions. Overall, this review suggests the therapeutic potential of UDCA in neurodegenerative disorders, proposing UDCA as a potential alternative therapeutic approach for patients suffering from these diseases.
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影响因子：
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作者：
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