Nucleophosmin is essential for c-Myc nucleolar localization and c-Myc-mediated rDNA transcription.
Nucleophosmin is essential for c-Myc nucleolar localization and c-Myc-mediated rDNA transcription.
复制标题
DOI：
10.1038/onc.2012.227
复制
发表时间：
2013-04-11
期刊：
影响因子：
8
通讯作者：
Hann, S. R.
中科院分区：
文献类型：
--
作者：
Li, Z.;Hann, S. R.
The transcription factor c-Myc has a critical role in cell proliferation and growth. The control of ribosome biogenesis by c-Myc through the regulation of transcription mediated by all three RNA polymerases is essential for c-Myc-driven proliferation. Specifically, in the nucleolus, c-Myc has been shown to be recruited to ribosomal DNA and activate RNA polymerase (pol) I-mediated transcription of rRNA genes. In addition, c-Myc accumulates in nucleoli upon inhibition of the proteasome, suggesting nucleolar localization also has a role in c-Myc proteolysis. Nucleophosmin, a predominantly nucleolar protein, is also critical in ribosome biogenesis and, like c-Myc, is found overexpressed in many types of tumors. Previously we demonstrated that NPM directly interacts with c-Myc and controls c-Myc-induced hyperproliferation and transformation. Here, we show that NPM is necessary for the localization of c-Myc protein to nucleoli, whereas c-Myc nucleolar localization is independent of p53, Mdm2 and ARF. Conversely, high transient NPM expression enhances c-Myc nucleolar localization, leading to increased c-Myc proteolysis. In addition, NPM is necessary for the ability of c-Myc to induce rRNA synthesis in the nucleolus and constitutive NPM overexpression stimulates c-Myc-mediated rRNA synthesis. Taken together, these results demonstrate an essential role for NPM in c-Myc nucleolar localization and c-Myc-mediated rDNA transcription.
登录
查看更多内容
影响因子：
21.3
作者：
Grewal, SS;Li, L;Edgar, BA
通讯作者：
Edgar, BA
影响因子：
2.7
作者：
Stoldt, Stefan;Wenzel, Dirk;Happel, Nicole
通讯作者：
Happel, Nicole
影响因子：
5.3
作者：
Spotts, GD;Patel, SV;Hann, SR
通讯作者：
Hann, SR
影响因子：
64.8
作者：
Qi, Y;Gregory, MA;Hann, SR
通讯作者：
Hann, SR
C-MYC协调调节核糖体染色质重塑和粒细胞分化过程中的pol I可用性。
影响因子：
14.9
作者：
Poortinga G;Wall M;Sanij E;Siwicki K;Ellul J;Brown D;Holloway TP;Hannan RD;McArthur GA
通讯作者：
McArthur GA