Engineering the next generation of cell-based therapeutics.
Engineering the next generation of cell-based therapeutics.
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DOI：
10.1038/s41573-022-00476-6
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发表时间：
2022-09
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影响因子：
--
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--
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基于细胞的疗法是一种新兴的治疗方法，有可能通过独特的强大作用模式来治疗许多目前难以治疗的疾病。尽管最近在临床和商业上取得了显着的成功，但基于细胞的疗法仍然面临着限制其广泛转化和商业化的众多挑战，包括确定适当的细胞来源，生成足够可行、有效和安全的产品来满足患者和疾病的特定需求，以及开发可扩展的制造工艺。这些障碍正在通过使用由下一代工程方法驱动的尖端基础研究来解决，包括基因组和表观基因组编辑、合成生物学和生物材料的使用。细胞疗法的广泛临床转化和商业化受到细胞来源、活力、效力、安全性和可扩展性相关挑战的阻碍。在这里，Veiseh 及其同事概述了基于细胞的疗法的开发进展，并讨论了生物工程方法（包括基因组编辑、合成生物学和生物材料的使用）如何开始解决该领域的关键挑战。
Cell-based therapeutics are an emerging modality with the potential to treat many currently intractable diseases through uniquely powerful modes of action. Despite notable recent clinical and commercial successes, cell-based therapies continue to face numerous challenges that limit their widespread translation and commercialization, including identification of the appropriate cell source, generation of a sufficiently viable, potent and safe product that meets patient- and disease-specific needs, and the development of scalable manufacturing processes. These hurdles are being addressed through the use of cutting-edge basic research driven by next-generation engineering approaches, including genome and epigenome editing, synthetic biology and the use of biomaterials. The widespread clinical translation and commercialization of cell-based therapies are hampered by challenges related to cell source, viability, potency, safety and scalability. Here, Veiseh and colleagues overview progress in the development of cell-based therapeutics and discuss how biological engineering approaches — including genome editing, synthetic biology and the use of biomaterials — are beginning to address key challenges in the field.
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影响因子：
28.1
作者：
Bose S;Volpatti LR;Thiono D;Yesilyurt V;McGladrigan C;Tang Y;Facklam A;Wang A;Jhunjhunwala S;Veiseh O;Hollister-Lock J;Bhattacharya C;Weir GC;Greiner DL;Langer R;Anderson DG
通讯作者：
Anderson DG
影响因子：
4.7
作者：
Abedi, Mohamad H.;Lee, Justin;Shapiro, Mikhail G.
通讯作者：
Shapiro, Mikhail G.
影响因子：
16.2
作者：
Calafiore, R;Basta, G;Brunetti, P
通讯作者：
Brunetti, P
影响因子：
64.8
作者：
Abudayyeh OO;Gootenberg JS;Essletzbichler P;Han S;Joung J;Belanto JJ;Verdine V;Cox DBT;Kellner MJ;Regev A;Lander ES;Voytas DF;Ting AY;Zhang F
通讯作者：
Zhang F
影响因子：
23.9
作者：
Black, Joshua B.;Adler, Andrew F.;Wang, Hong-Gang;D'Ippolito, Anthony M.;Hutchinson, Hunter A.;Reddy, Timothy E.;Pitt, Geoffrey S.;Leong, Kam W.;Gersbach, Charles A.
通讯作者：
Gersbach, Charles A.