Redistribution of inhibitory force feedback between a long toe flexor and the major ankle extensor muscles following spinal cord injury.
Redistribution of inhibitory force feedback between a long toe flexor and the major ankle extensor muscles following spinal cord injury.
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DOI：
10.1002/jnr.24630
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发表时间：
2020-08
影响因子：
4.2
通讯作者：
Nichols, T. Richard
中科院分区：
文献类型：
--
作者：
Niazi, Irrum F.;Lyle, Mark A.;Rising, Aaron;Howland, Dena R.;Nichols, T. Richard
来自高尔基腱器官的抑制通路在跨越不同关节和旋转轴的肌肉之间广泛投射。有证据表明，这种肌间抑制的强度和分布取决于运动任务和来自脑干的相应信号。本研究的目的是调查脊髓半切后这种感觉网络是否发生改变，作为脊髓损伤后观察到的运动缺陷的潜在解释。对未麻醉的去大脑雌性猫后肢的长趾屈肌和踝跖屈肌（拇长屈肌）以及三个主要踝伸肌（腓肠肌、比目鱼肌和跖肌的组合）之间的力反馈进行了评估。数据收集自具有完整脊髓（对照）和侧脊髓半切 (LSH) 的动物，包括慢性 LSH（4-20 周）、亚慢性 LSH（2 周）和急性 LSH。肌肉被单独拉伸和成对组合拉伸，以测量脚趾屈肌和每个踝关节伸肌之间的肌间反馈。在对照动物中观察到三种模式（脚趾屈肌和踝伸肌之间的平衡抑制，从脚趾屈肌到踝伸肌的更强抑制，反之亦然）。脊柱半切后，仅观察到脚趾屈肌对踝关节伸肌的强烈抑制，与生存时间无关。结果表明受伤脊髓中的力反馈立即且永久地重组。脊髓损伤后力反馈强度和分布的改变可能是未来康复的重要目标。高尔基腱器官通路有助于在运动任务（包括运动）期间协调肢体伸肌。通常，这些抑制力反馈途径是灵活加权的。我们表明，脊髓损伤后，力反馈会永久重组。失去平衡，并且从脚趾屈肌到踝关节伸肌出现偏向抑制。
Inhibitory pathways from Golgi tendon organs project widely between muscles crossing different joints and axes of rotation. Evidence suggests that the strength and distribution of this intermuscular inhibition is dependent on motor task and corresponding signals from the brainstem. The purpose of the present study was to investigate whether this sensory network is altered after spinal cord hemisection as a potential explanation for motor deficits observed after spinal cord injury. Force feedback was assessed between the long toe flexor and ankle plantarflexor (flexor hallucis longus), and the three major ankle extensors, (combined gastrocnemius, soleus and plantaris muscles) in the hind limbs of unanesthetized, decerebrate, female, cats. Data were collected from animals with intact spinal cords (control) and lateral spinal hemisections (LSHs) including chronic LSH (4–20 weeks), sub-chronic LSH (2 weeks) and acute LSH. Muscles were stretched individually and in pairwise combinations to measure intermuscular feedback between the toe flexor and each of the ankle extensors. In control animals three patterns were observed (balanced inhibition between toe flexor and ankle extensors, stronger inhibition from toe flexor to ankle extensor or vice versa). Following spinal hemisection, only strong inhibition from toe flexors onto ankle extensors was observed independent of survival time. The results suggest immediate and permanent reorganization of force feedback in the injured spinal cord. The altered strength and distribution of force feedback after spinal cord injury may be an important future target for rehabilitation. Golgi tendon organ pathways contribute to coordination of limb extensors during motor tasks including locomotion. Normally, these inhibitory force feedback pathways are flexibly weighted. We show that following spinal cord injury, force feedback is permanently reorganized. Balance is lost and biased inhibition emerges from toe flexors onto ankle extensors.
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