Relationship between Quantitative Parameters of Echocardiography and Vascular Endothelial Function in Patients with Chronic Heart Failure and Its Predictive Value for Short-Term MACE Risk.
Relationship between Quantitative Parameters of Echocardiography and Vascular Endothelial Function in Patients with Chronic Heart Failure and Its Predictive Value for Short-Term MACE Risk.
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慢性心力衰竭患者超声心动图定量参数与血管内皮功能的关系及其对短期MACE风险的预测价值
DOI：
10.1155/2021/1985962
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发表时间：
2021
影响因子：
--
通讯作者：
Wang R
中科院分区：
文献类型：
--
作者：
Dai M;Wang Y;Peng L;Liu X;Lu J;He L;Li K;Qian D;Wang R
目的探讨慢性心力衰竭（CHF）患者超声心动图定量参数与血管内皮功能的关系及短期主要心血管不良事件（MACE）的预测价值。方法选择2018年2月~ 2020年2月我院收治的CHF患者86例作为观察组，同期选取健康者46例作为对照组。比较两组超声心动图定量参数（左室射血分数（LVEF）、左室短轴缩短率（FS）、二尖瓣舒张早、晚期峰值流速比（E/A））和内皮功能指标(内皮素-1 （ET-1)/一氧化氮（NO））。分析CHF患者超声心动图定量参数与血管内皮功能的相关性。采用logistic回归方程分析CHF患者发生MACE的危险因素。采用受试者工作特征曲线（ROC）分析超声心动图定量参数及NO/ET-1对CHF患者MACE发生风险的预测价值。结果观察组患者LVEF、FS、NO/ET-1均低于对照组，E/A高于对照组，差异有统计学意义（P < 0.05）。CHF患者LVEF、FS与NO/ET-1呈正相关，E/A与NO/ET-1呈负相关（P < 0.05）。Logistic回归分析显示，调整年龄、体重指数、心功能分级后，LVEF、FS、NO/ET-1、E/A降低是MACE发生的危险因素（P < 0.05）。超声心动图定量参数与NO/ET-1联合预测短期MACE的AUC值为0.883，敏感性为86.21%，特异性为73.13%。结论CHF患者超声心动图定量参数与血管内皮功能相关，两者结合可有效预测近期发生MACE的风险，为临床治疗提供参考。
Objective To investigate the relationship between quantitative parameters of echocardiography and vascular endothelial function in patients with chronic heart failure (CHF) and the predictive value of short-term major adverse cardiovascular events (MACE). Methods From February 2018 to February 2020, 86 CHF patients in our hospital were selected as the observation group, and 46 healthy subjects were selected as the control group during the same period. Quantitative parameters of echocardiography (left ventricular ejection fraction (LVEF), left ventricular short-axis shortening rate (FS), and ratio of peak flow velocity between early and late mitral valve diastole (E/A)) and endothelial function indexes (endothelin-1 (ET-1)/nitric oxide (NO)) were compared between the two groups. The correlation between quantitative parameters of echocardiography and vascular endothelial function in patients with CHF was analyzed. A logistic regression equation was used to analyze the risk factors of MACE in patients with CHF. The receiver operating characteristic curve (ROC) was used to analyze the predictive value of quantitative parameters of echocardiography and NO/ET-1 for the risk of MACE in patients with CHF. Result LVEF, FS, and NO/ET-1 in the observation group were lower than those in the control group, while E/A was higher than that in the control group (P < 0.05). In CHF patients, LVEF and FS were positively correlated with NO/ET-1, while E/A was negatively correlated with NO/ET-1 (P < 0.05). Logistic regression analysis showed that the decrease of LVEF, FS, NO/ET-1, and E/A were risk factors for MACE (P < 0.05) after adjusting for age, body mass index, and cardiac function grading. The AUC value of short-term MACE predicted by quantitative parameters of echocardiography and NO/ET-1 combined was 0.883, with a corresponding sensitivity of 86.21% and specificity of 73.13%. Conclusion Quantitative parameters of echocardiography in CHF patients are related to vascular endothelial function, and their combination can effectively predict the risk of MACE in the near future, providing reference for clinical treatment.
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DOI：
10.1136/heartjnl-2017-312539
发表时间：
2018-06
期刊：
Heart (British Cardiac Society)
影响因子：
--
作者：
Witte KK;Patel PA;Walker AMN;Schechter CB;Drozd M;Sengupta A;Byrom R;Kearney LC;Sapsford RJ;Kearney MT;Cubbon RM
通讯作者：
Cubbon RM
DOI：
10.1007/s10554-020-01889-3
发表时间：
2020-05-22
影响因子：
2.1
作者：
Szymczyk, Tobias;Sauzet, Odile;Fox, Henrik
通讯作者：
Fox, Henrik
影响因子：
5.3
作者：
Wagholikar KB;Fischer CM;Goodson A;Herrick CD;Rees M;Toscano E;MacRae CA;Scirica BM;Desai AS;Murphy SN
通讯作者：
Murphy SN
影响因子：
5
作者：
Hammoudi, Nadjib;Laveau, Florent;Isnard, Richard
通讯作者：
Isnard, Richard
影响因子：
1.6
作者：
Qin, Limin;Liu, Xiaohong;Li, Yi
通讯作者：
Li, Yi