Hepatoma-Derived Growth Factor Secreted from Mesenchymal Stem Cells Reduces Myocardial Ischemia-Reperfusion Injury.
Hepatoma-Derived Growth Factor Secreted from Mesenchymal Stem Cells Reduces Myocardial Ischemia-Reperfusion Injury.
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间充质干细胞分泌的肝癌衍生生长因子可减少心肌缺血再灌注损伤
DOI：
10.1155/2017/1096980
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发表时间：
2017
影响因子：
4.3
通讯作者：
Wang JA
中科院分区：
文献类型：
--
作者：
Zhou Y;Chen P;Liu Q;Wang Y;Zhang L;Wu R;Chen J;Yu H;Zhu W;Hu X;Wang JA
The present study aimed to explore the major factors that account for the beneficial effects of mesenchymal stem cells (MSCs). Using isobaric tags for relative and absolute quantitation method, hepatoma-derived growth factor (HDGF) was identified as an important factor secreted by MSCs, but not by cardiac fibroblasts (CFs). The protective effects of conditioned medium (CdM) from MSCs or CFs were tested by using either H9C2 cells that were exposed by hypoxia-reoxygenation (H/R) insult or an in vivo mouse model of myocardial ischemia-reperfusion. Compared to CF-CdM, MSC-CdM conferred protection against reperfusion injury. CdM obtained from MSCs that were treated with HDGF-targeted shRNA failed to offer any protection in vitro. In addition, administration of recombinant HDGF alone recapitulated the beneficial effects of MSC-CdM, which was associated with increased protein kinase C epsilon (PKCε) phosphorylation, enhanced mitochondria aldehyde dehydrogenase family 2 activity, and decreased 4-hydroxy-2-nonenal accumulation. A significant decrease in infarct size and ameliorated cardiac dysfunction was achieved by administration of HDGF in wild-type mice, which was absent in PKCε dominant negative mice, indicating the essential roles of PKCε in HDGF-mediated protection. HDGF secreted from MSCs plays a key role in the protection against reperfusion injury through PKCε activation.
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从间充质干细胞释放的肝素酶激活整联蛋白beta1/hif-2alpha/flk-1信号传导，并促进内皮细胞迁移和血管生成。
影响因子：
5.2
作者：
Hu, Xinyang;Zhang, Ling;Jin, Jing;Zhu, Wei;Xu, Yinchuan;Wu, Yan;Wang, Yingchao;Chen, Han;Webster, Keith A.;Chen, Huiqiang;Yu, Hong;Wang, Jian'an
通讯作者：
Wang, Jian'an
影响因子：
37.8
作者：
Roger VL;Go AS;Lloyd-Jones DM;Benjamin EJ;Berry JD;Borden WB;Bravata DM;Dai S;Ford ES;Fox CS;Fullerton HJ;Gillespie C;Hailpern SM;Heit JA;Howard VJ;Kissela BM;Kittner SJ;Lackland DT;Lichtman JH;Lisabeth LD;Makuc DM;Marcus GM;Marelli A;Matchar DB;Moy CS;Mozaffarian D;Mussolino ME;Nichol G;Paynter NP;Soliman EZ;Sorlie PD;Sotoodehnia N;Turan TN;Virani SS;Wong ND;Woo D;Turner MB;American Heart Association Statistics Committee and Stroke Statistics Subcommittee
通讯作者：
American Heart Association Statistics Committee and Stroke Statistics Subcommittee
影响因子：
2.1
作者：
Jiang, Zhi-Sheng;Wen, Ge-Bo;Kardami, Elissavet
通讯作者：
Kardami, Elissavet
影响因子：
2.5
作者：
Everett, AD
通讯作者：
Everett, AD
影响因子：
37.8
作者：
MURRY, CE;JENNINGS, RB;REIMER, KA
通讯作者：
REIMER, KA