Suppression of efferent limb of testicular autoimmune response by a regulatory CD4+ T cell line in mice
Suppression of efferent limb of testicular autoimmune response by a regulatory CD4+ T cell line in mice
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调节性 CD4 T 细胞系抑制小鼠睾丸自身免疫反应的传出肢
DOI：
10.1111/j.1365-2249.1992.tb03019.x
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发表时间：
1992
影响因子：
4.6
通讯作者：
K. Hojo
中科院分区：
文献类型：
--
作者：
M. Itoh;A. Mukasa;Y. Tokunaga;C. Hiramine;K. Hojo
建立了一株小鼠T细胞系（简称C.Ts），可作为抑制实验性自身免疫性睾丸炎（EAO）的免疫介质。用睾丸生殖细胞（TC）超免疫C3 H/He小鼠，制备脾细胞，用小鼠睾丸抗原（mTA）刺激，体外反复筛选淋巴细胞，建立C.Ts细胞系。C.Ts细胞为Thy 1.2+、表面免疫球蛋白、CD 3+、CD 4+和CD 8 −。仅在疾病的临床前阶段（自身免疫反应的传出支），当转移到主动EAO致敏小鼠中时，细胞可以抑制EAO的诱导。转移的C.Ts细胞以抗原特异性方式显著抑制受体中对TC的细胞和体液免疫应答。发现C.Ts细胞的疾病抑制依赖于它们的细胞数量，并且它们的抑制活性通过用m TA体外刺激而显著增强。
A murine T cell line (designated as C.Ts) as a mediatofof suppression of experimental autoimmune orchitis (EAO) was established. The method of establishment of C.Ts cell line was preparing spleen cells from C3H/He mice hyperimmunized with testicular germ cells (TC)and the repeated selection of the lymphocytes in vitro by stimulation with mouse testicular antigens (mTA). The C.Ts cells were Thy 1.2+, surface immunoglobulin, CD3+, CD4+ and CD8−. The cells could suppress the induction of EAO when transferred into actively EAO‐sensitized mice only at the pre‐clinical stage of the disease (efferent limb of the autoimmune response). The transferred C.Ts cells significantly inhibited both cellular and humoral immune responses to TC in the recipients in an antigen‐specific manner. The disease suppression by C.Ts cells was found to depend upon their cell number, and their suppressive activity was markedly augmented by in vitro stimulation with m TA.
CD4细胞能够抑制胶原蛋白诱导的关节炎。
DOI：
--
发表时间：
1989
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Myers,LK;Stuart,JM;Kang,AH
通讯作者：
Kang,AH
T 淋巴细胞克隆阐明了发病机制并影响实验性关节炎的治疗。
影响因子：
--
作者：
Cohen,IR;Holoshitz,J;vanEden,W;Frenkel,A
通讯作者：
Frenkel,A