Relationship between obesity-related colorectal tumors and the intestinal microbiome: an animal-based trial
Relationship between obesity-related colorectal tumors and the intestinal microbiome: an animal-based trial
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肥胖相关结直肠肿瘤与肠道微生物组之间的关系：基于动物的试验
DOI：
10.1007/s00432-022-04477-1
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发表时间：
2022
影响因子：
3.6
通讯作者：
Kitagawa Yuko
中科院分区：
文献类型：
--
作者：
Iwama Nozomi;Matsuda Mutsuhito;Tsuruta Masashi;Okabayashi Koji;Shigeta Kohei;Kanai Takanori;Kitagawa Yuko
目的肥胖是结直肠癌（CRC）的一个危险因素，肠道微生物组被认为是CRC和肥胖的原因。尽管如此，肠道微生物组在肥胖相关CRC中的作用尚不清楚。本研究旨在阐明肥胖相关的CRC和肠道微生物组之间的关系，使用mouse model.MethodsWe比较肥胖和胰岛素抵抗的2型糖尿病小鼠模型[KKAy]野生型小鼠（WT）[C57 BL/6 J]。腹腔注射氧化偶氮甲烷以建立小鼠CRC模型。在26周时，我们比较了肿瘤数量和肠道微生物组。我们还比较了它们在两个模型，即抗生素鸡尾酒和co-housing.ResultsIn所有模型，KKAy小鼠有一个显着更多的肿瘤比WT小鼠。分析表明，两种模型中肠道微生物组的分布都发生了变化;然而，没有观察到肿瘤发展的差异。肿瘤表达仅在WT的抗生素鸡尾酒模型中受到抑制，而KKAy小鼠具有肿瘤（C57 B1/6 J：KKAy，0/9：8/8;p< 0.001）。KKAy小鼠在所有treatment.ConclusionBased上的结果，肠道微生物组可能不与肥胖相关的CRC的肿瘤发生。可能有必要考虑与肥胖相关的CRC相关的其他事实。
PurposeObesity is a risk factor for colorectal cancer (CRC), and the intestinal microbiome is considered to contribute to CRC and obesity. Nonetheless, the role of the intestinal microbiome in obesity-related CRC is unclear. This study aimed to clarify the relationship between obesity-related CRC and the intestinal microbiome using a mouse model.MethodsWe compared an obese and insulin-resistant type 2 diabetes mouse model [KKAy] to wild-type mice (WT) [C57BL/6 J]. Azoxymethane was intraperitoneally injected to develop a mouse model CRC. At 26 weeks, we compared the number of tumors and the intestinal microbiome. We also compared them across two models, namely, antibiotic cocktail and co-housing.ResultsIn all models, KKAy mice had a significantly greater number of tumors than WT mice. Analysis showed that the distribution of the intestinal microbiome changed in both models; however, no difference in tumor development was observed. Tumor expression was suppressed only in the antibiotic cocktail model of WT, whereas KKAy mice bore tumors (C57Bl/6 J: KKAy, 0/9:8/8;p< 0.001). KKAy mice remained predominantly tumor-bearing in all treatments.ConclusionBased on the results, the intestinal microbiome may not be associated with tumorigenesis in obesity-related CRC. It may be necessary to think of other facts linked to obesity-related CRC.
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