Metabolic risk factors and risk of Covid-19: A systematic review and meta-analysis.
Metabolic risk factors and risk of Covid-19: A systematic review and meta-analysis.
复制标题
DOI：
10.1371/journal.pone.0243600
复制
发表时间：
2020
期刊：
影响因子：
3.7
通讯作者：
Broumand B
中科院分区：
文献类型：
--
作者：
Moazzami B;Chaichian S;Kasaeian A;Djalalinia S;Akhlaghdoust M;Eslami M;Broumand B
根据2019冠状病毒病发病率的流行病学研究结果，疾病和死亡率似乎与代谢风险因素有关。本系统性综述和荟萃分析旨在评估代谢风险因素与Covid-19风险的相关性。本研究根据PRISMA指南设计。两名独立的研究人员使用PubMed、Web of Science、科克伦图书馆和Scopus搜索相关研究。搜索词的开发集中在“Covid-19”和“代谢风险因素”的两个主要根源上。所有相关的观察性、分析性研究、综述文章和对成人人群的荟萃分析均纳入本荟萃分析。使用合并比例的随机效应模型进行荟萃分析，以解决研究间的异质性。使用STATA软件包版本11.2（StataCorp，USA）分析数据。通过对目标数据库的全面系统检索，共检索到1124篇文献，经整理后纳入13篇研究。COVID-19患者的肥胖合并患病率为29%（95%CI：14-47%）。对于糖尿病和高血压，这些分别为22%（95% CI：12%-33%）和32%（95% CI：12%-56%）。三个合并患病率的估计值存在显著异质性，没有任何显著的小规模研究效应。这些警告点在一定程度上指导医生和临床医生更好地理解控制共病风险因素在优先资源分配和干预措施中的重要性。荟萃分析显示，在新冠肺炎患者中，高血压的患病率高于肥胖和糖尿病。为了更好地管理公共卫生疫苗接种和其他必要干预措施，必须采用共病代谢风险因素的流行率。研究结果可能有助于改善COVID-19患者的服务提供，同时有助于制定更好的政策来预防和应对COVID-19及其关键结果。
Based on the epidemiologic findings of Covid-19 incidence; illness and mortality seem to be associated with metabolic risk factors. This systematic review and meta-analysis aimed to assess the association of metabolic risk factors and risk of Covid-19. This study was designed according to PRISMA guidelines. Two independent researchers searched for the relevant studies using PubMed, Web of Science, Cochrane Library, and Scopus. The search terms developed focusing on two main roots of “Covid-19” and “metabolic risk factors”. All relevant observational, analytical studies, review articles, and a meta-analysis on the adult population were included in this meta-analysis. Meta-analysis was performed using the random effect model for pooling proportions to address heterogeneity among studies. Data were analyzed using STATA package version 11.2, (StataCorp, USA). Through a comprehensive systematic search in the targeted databases we found 1124 papers, after running the proses of refining, 13 studies were included in the present meta-analysis. The pooled prevalence of obesity in Covid-19 patients was 29% (95% CI: 14–47%). For Diabetes and Hypertension, these were 22% (95% CI: 12% 33%) and 32% (95% CI: 12% 56%), respectively. There was significant heterogeneity in the estimates of the three pooled prevalence without any significant small-study effects. Such warning points, to some extent, guide physicians and clinicians to better understand the importance of controlling co-morbid risk factors in prioritizing resource allocation and interventions. The meta-analysis showed that hypertension is more prevalent than obesity and diabetes in patients with Covid-19 disease. The prevalence of co-morbid metabolic risk factors must be adopted for better management and priority settings of public health vaccination and other required interventions. The results may help to improve services delivery in COVID-19 patients, while helping to develop better policies for prevention and response to COVID-19 and its critical outcomes.
登录
查看更多内容
影响因子：
24.3
作者：
Guan, Wei-jie;Liang, Wen-hua;He, Jian-xing
通讯作者：
He, Jian-xing
影响因子：
3.5
作者：
Joensen, L. E.;Madsen, K. P.;Willaing, I.
通讯作者：
Willaing, I.
影响因子：
2.2
作者：
DerSimonian R;Laird N
通讯作者：
Laird N
DOI：
10.1016/j.dsx.2020.04.050
发表时间：
2020-07-01
影响因子：
10
作者：
Hastie, Claire E.;Mackay, Daniel F.;Pell, Jill P.
通讯作者：
Pell, Jill P.
影响因子：
2
作者：
Higgins, JPT;Thompson, SG
通讯作者：
Thompson, SG