Effect of serum electrolytes within normal ranges on QTc prolongation: a cross-sectional study in a Chinese rural general population.
Effect of serum electrolytes within normal ranges on QTc prolongation: a cross-sectional study in a Chinese rural general population.
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DOI：
10.1186/s12872-018-0906-1
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发表时间：
2018-08-29
影响因子：
2.1
通讯作者：
Sun Y
中科院分区：
文献类型：
--
作者：
Chen Y;Guo X;Sun G;Li Z;Zheng L;Sun Y
许多先前的临床研究已经报道，经心率校正的QT间期（QTc）延长与心源性猝死和全因死亡的风险增加相关。本研究旨在探讨中国东北农村一般人群中血清电解质与QTc间期延长之间的关系。我们进行了一项横断面研究，包括2012年至2013年辽宁省10，334名（4820名男性和5514名女性）≥35岁的普通人群。由经过培训的人员收集人体测量、实验室检查和自我报告的生活方式因素信息、超声心动图和心电图。采用多元线性回归和Logistic回归分析检测血清电解质与QTc间期延长之间的关系。QTc间期正常组为415.6 ± 18.8 ms，延长组为470.1 ± 23.1 ms。QTc间期延长的发生率随着血清钾的降低和镁的升高而显著增加。多元逐步线性回归分析显示，年龄、高血压、腰围与QTc间期呈显著正相关。但血钾与QTc间期呈显著负相关。血清镁、钙与QTc间期呈正相关。多因素Logistic回归分析显示，血钾水平越低，QTc间期延长的风险越大，尤其是女性（Q2 vs. Q4：OR：1.54，95%CI：1.01-2.35; Q1 vs. Q4：OR：2.02，95%CI：1.36-3.01）。此外，较高的血清镁增加了QTc延长的风险，仅在男性人群中有显著性差异。在目前中国农村一般人群中，即使在正常范围内，血清钾降低和血清镁升高也是QTc延长的重要危险因素。本文的在线版本（10.1186/s12872-018-0906-1）包含补充材料，可供授权用户使用。
Many previous clinical studies have reported that prolongation of the QT interval corrected for heart rate (QTc) is associated with an increased risk of sudden cardiac death and all-cause mortality. This study aimed to explore associations between serum electrolytes and QTc prolongation in the north-eastern Chinese rural general population. We performed a cross-sectional study including 10,334 (4820 men and 5514 women) from the general population aged ≥35 years in the Liaoning Province from 2012 to 2013. Anthropometric measurements, laboratory examinations and self-reported lifestyle factor information, echocardiography and electrocardiogram were collected by trained personnel. The associations between serum electrolytes and QTc prolongation were tested using multiple linear regression and logistic regression analyses. The mean QTc interval were 415.6 ± 18.8 and 470.1 ± 23.1 ms in normal group and QTc prolongation group respectively. The prevalence of QTc prolongation increased significantly with a decrease in serum potassium and an increase in magnesium. Stepwise multiple linear regression showed that age, hypertension, waist circumference were prominently positive associated with QTc interval both in male and female population. But serum potassium was significantly inversely associated with QTc interval. Serum magnesium and calcium also showed a positive relationship with QTc interval. Furthermore, multiple logistic regression found that lower quartile of serum potassium had higher risk for QTc prolongation, especially in female population (Q2 vs. Q4: OR: 1.54, 95%CI: 1.01–2.35; Q1 vs. Q4: OR: 2.02, 95%CI: 1.36–3.01). In addition, the higher serum magnesium increased the risk of QTc prolongation, which was significantly only in male population. In present Chinese rural general population, even with normal range, a decrease in serum potassium and an increase in serum magnesium are important risk factors for QTc prolongation. The online version of this article (10.1186/s12872-018-0906-1) contains supplementary material, which is available to authorized users.
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