Effect of tocilizumab on haematological markers implicates interleukin-6 signalling in the anaemia of rheumatoid arthritis.
Effect of tocilizumab on haematological markers implicates interleukin-6 signalling in the anaemia of rheumatoid arthritis.
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DOI：
10.1186/ar4397
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发表时间：
2013
影响因子：
4.9
通讯作者：
Bernasconi C
中科院分区：
文献类型：
--
作者：
Isaacs JD;Harari O;Kobold U;Lee JS;Bernasconi C
我们的目的是确定类风湿关节炎（RA）患者白细胞介素（IL）-6受体抑制与血红蛋白，急性期反应物和铁代谢标志物（包括铁调素）的相互关系。对MEASURE研究中接受托珠单抗或安慰剂的患者数据进行分析。我们研究了基线和托珠单抗治疗期间血红蛋白、血红蛋白和铁稳态参数[铁蛋白、总铁结合能力（TIBC）、铁调素、触珠蛋白]、IL-6和急性期反应物[C反应蛋白（CRP）、红细胞沉降率（ESR）]之间的相关性，以确定血红蛋白水平升高的统计学相关性。在基线时，CRP和触珠蛋白与血红蛋白水平呈负相关（适度）。托珠单抗治疗后，CRP、铁调素、铁蛋白和触珠蛋白水平随着TIBC和血红蛋白的增加而下降。前2周CRP、铁调素和触珠蛋白水平的福尔斯下降与第12周TIBC和血红蛋白的升高相关。托珠单抗治疗的RA患者的炎性贫血得到改善这种改善与全身炎症的抑制程度、铁调素和触珠蛋白的减少以及铁结合能力的增加相关。这些临床数据提供了IL-6信号在RA炎性贫血中的作用的证据。
Our objective was to determine the interrelationships of interleukin (IL)-6 receptor inhibition with haemoglobin, acute-phase reactants and iron metabolism markers (including hepcidin) in patients with rheumatoid arthritis (RA). Data of patients receiving tocilizumab or placebo in the MEASURE study were analysed. We investigated associations at baseline and during tocilizumab treatment among haemoglobin, parameters of haemoglobin and iron homeostasis [ferritin, total iron-binding capacity (TIBC), hepcidin, haptoglobin], IL-6 and acute-phase reactants [C-reactive protein (CRP), erythrocyte sedimentation rate (ESR)] to identify statistical correlates of rise in haemoglobin level. At baseline, CRP and haptoglobin were inversely correlated (modestly) with haemoglobin levels. After treatment with tocilizumab, CRP, hepcidin, ferritin and haptoglobin levels fell alongside increases in TIBC and haemoglobin. The falls in CRP, hepcidin and haptoglobin levels in the first 2 weeks correlated with a week 12 rise in TIBC and haemoglobin. Inflammatory anaemia improves in patients with RA treated with tocilizumab. This improvement correlates with the degree of suppression of systemic inflammation, reduction in hepcidin and haptoglobin and increase in iron-binding capacity. These clinical data provide evidence of a role for IL-6 signalling in the inflammatory anaemia of RA.
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影响因子：
20.3
作者：
Kemna, E;Pickkers, P;Swinkels, D
通讯作者：
Swinkels, D
影响因子：
4
作者：
Hashizume, Misato;Uchiyama, Yasushi;Mihara, Masahiko
通讯作者：
Mihara, Masahiko
影响因子：
27.4
作者：
Jones G;Sebba A;Gu J;Lowenstein MB;Calvo A;Gomez-Reino JJ;Siri DA;Tomsic M;Alecock E;Woodworth T;Genovese MC
通讯作者：
Genovese MC
DOI：
10.1182/asheducation-2010.1.276
发表时间：
2010-12-01
期刊：
HEMATOLOGY-AMERICAN SOCIETY HEMATOLOGY EDUCATION PROGRAM
影响因子：
--
作者：
Roy, Cindy N.
通讯作者：
Roy, Cindy N.
影响因子：
56.9
作者：
Nemeth, E;Tuttle, MS;Kaplan, J
通讯作者：
Kaplan, J