The functional brain favours segregated modular connectivity at old age unless affected by neurodegeneration.
The functional brain favours segregated modular connectivity at old age unless affected by neurodegeneration.
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DOI：
10.1038/s42003-021-02497-0
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发表时间：
2021-08-16
影响因子：
5.9
通讯作者：
Taylor JP
中科院分区：
文献类型：
--
作者：
Chen X;Necus J;Peraza LR;Mehraram R;Wang Y;O'Brien JT;Blamire A;Kaiser M;Taylor JP
大脑的模块化连接赋予了这个器官弹性和适应性。衰老过程改变了大脑的组织模块性，而神经退行性病变进一步加剧了这些变化，导致组织混乱。为了进一步了解这一点，我们分析了两个衰老队列和一个神经退行性疾病混合队列中的模块变异性（模块的异质性）和模块解离（与隔离连接的脱离）。我们的结果表明，大脑在元认知大脑区域（关联皮层）中遵循高模块化变异性的普遍模式。尽管模块异质性增加，但衰老过程中的大脑仍朝着分离的模块化结构发展——老年人的模块不仅是分离的，而且它们的形状和大小比年轻人的变化更大。在存在神经退行性疾病的情况下，大脑在整体上保持其隔离的连接，但在局部则不然，这在路易体痴呆和帕金森病痴呆中尤其明显；总体而言，模块化大脑显示出不同的病理模式。 Chen 等人使用功能磁共振成像研究了两个老年群体和一个神经退行性疾病混合群体的大脑连接性。他们证明，随着年龄的增长，大脑会朝着更加隔离的模块化结构发展，但这会被神经退行性疾病所破坏。
Brain’s modular connectivity gives this organ resilience and adaptability. The ageing process alters the organised modularity of the brain and these changes are further accentuated by neurodegeneration, leading to disorganisation. To understand this further, we analysed modular variability—heterogeneity of modules—and modular dissociation—detachment from segregated connectivity—in two ageing cohorts and a mixed cohort of neurodegenerative diseases. Our results revealed that the brain follows a universal pattern of high modular variability in metacognitive brain regions: the association cortices. The brain in ageing moves towards a segregated modular structure despite presenting with increased modular heterogeneity—modules in older adults are not only segregated, but their shape and size are more variable than in young adults. In the presence of neurodegeneration, the brain maintains its segregated connectivity globally but not locally, and this is particularly visible in dementia with Lewy bodies and Parkinson’s disease dementia; overall, the modular brain shows patterns of differentiated pathology. Chen at al used fMRI to study the brain connectivity in two ageing cohorts and a mixed cohort of patients with neurodegenerative diseases. They demonstrated that with ageing the brain moves towards a more segregated modular structure, however this is disrupted by neurodegenerative diseases.
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DOI：
10.1093/cercor/bhw157
发表时间：
2016-08
期刊：
Cerebral cortex (New York, N.Y. : 1991)
影响因子：
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DOI：
10.1073/pnas.1220826110
发表时间：
2013-07-09
影响因子：
11.1
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