Efficiency and cost of economical brain functional networks.
Efficiency and cost of economical brain functional networks.
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DOI：
10.1371/journal.pcbi.0030017
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发表时间：
2007-02-02
影响因子：
4.3
通讯作者：
Bullmore E
中科院分区：
文献类型：
--
作者：
Achard S;Bullmore E
大脑解剖网络稀疏，复杂且具有经济小世界的特性。 ;平均年龄= 66.5岁）和健康的年轻人（n = 15;平均年龄= 24.7岁）志愿者在安慰剂或A后两次扫描两次单剂量的多巴胺受体拮抗剂（硫酸盐400 mg）通过小波相关性分析估计90个皮层和皮层区域之间的功能连通性，并以0.06-0.11 Hz的速度估算 - 在提供低连接成本的平行信息处理的高度和局部效率方面，世界和经济性老年人的成本不成比例，并且年龄对效率的有害影响本地化为额叶和临时皮质和皮层下区域，多巴胺拮抗剂也损害了该网络的全球和局部效率，但这种效果与该效应差异化，但与该效果相互作用，并且与该效果差异化，并且与该效果差异化，并且与该网络的局部效果差异化，并且没有与之相互作用。年龄的影响。多巴胺传播的衰老和药物阻断。
越来越多的证据表明，在潜水员领域以及广泛的空间和时间尺度上，许多复杂的网络可能具有共同的拓扑特性。网络既具有连接的本地聚类，也有任何一对节点之间的短路径长度。平行信息的局部效率和许多网络在支持低成本的感觉上是经济的表明人脑功能网络具有经济的小世界特性，并且这些网络的经济性能在有害，但受正常衰老的影响，并通过使用A多巴胺受体拮抗剂说明了进一步探索对人脑功能网络的发育，病理和药物影响的概念和技术。
Brain anatomical networks are sparse, complex, and have economical small-world properties. We investigated the efficiency and cost of human brain functional networks measured using functional magnetic resonance imaging (fMRI) in a factorial design: two groups of healthy old (N = 11; mean age = 66.5 years) and healthy young (N = 15; mean age = 24.7 years) volunteers were each scanned twice in a no-task or “resting” state following placebo or a single dose of a dopamine receptor antagonist (sulpiride 400 mg). Functional connectivity between 90 cortical and subcortical regions was estimated by wavelet correlation analysis, in the frequency interval 0.06–0.11 Hz, and thresholded to construct undirected graphs. These brain functional networks were small-world and economical in the sense of providing high global and local efficiency of parallel information processing for low connection cost. Efficiency was reduced disproportionately to cost in older people, and the detrimental effects of age on efficiency were localised to frontal and temporal cortical and subcortical regions. Dopamine antagonism also impaired global and local efficiency of the network, but this effect was differentially localised and did not interact with the effect of age. Brain functional networks have economical small-world properties—supporting efficient parallel information transfer at relatively low cost—which are differently impaired by normal aging and pharmacological blockade of dopamine transmission. It is increasingly evident that many complex networks, in diverse fields and over a wide range of spatial and time scales, may have topological properties in common. These unifying organizational principles have been described in terms of “small-world” parameters—meaning that many networks have both local clustering of connections and a short path length between any pair of nodes. Recent work has shown that we can also define small-world networks as having high global and local efficiency of parallel information transfer; and that many networks are economical in the sense of supporting high efficiency for low cost. Here we extend these ideas for the first time to an analysis of human brain functional networks derived from functional magnetic resonance imaging data. We show that human brain functional networks have economical small-world properties and that economical performance of these networks is detrimentally but differently affected by normal aging and by treatment with a dopamine receptor antagonist. The results illustrate concepts and techniques that could be important in further exploration of developmental, pathological, and pharmacological effects on human brain functional networks. They are also likely to be generalisable to applications in other fields of computational biology.
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影响因子：
5.3
作者：
Achard, S;Salvador, R;Bullmore, ET
通讯作者：
Bullmore, ET
影响因子：
5.3
作者：
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通讯作者：
Di Lazzaro, V
影响因子：
4.3
作者：
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通讯作者：
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影响因子：
5.7
作者：
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通讯作者：
Breakspear, M
影响因子：
5.7
作者：
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通讯作者：
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