The association between cancer-related fatigue and diabetes from pre-chemotherapy to 6 months post-chemotherapy.
The association between cancer-related fatigue and diabetes from pre-chemotherapy to 6 months post-chemotherapy.
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DOI：
10.1007/s00520-022-07189-x
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发表时间：
2022-09
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影响因子：
--
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中科院分区：
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与无癌症病史的女性（对照）相比，量化乳腺癌女性从化疗前到化疗后 6 个月期间糖尿病与疲劳之间的关系。这是对接受化疗和对照的女性乳腺癌患者进行的全国性前瞻性纵向研究的二次分析。在基线时获得糖尿病诊断（是/否），并在患者化疗前、化疗后和化疗后 6 个月使用多维疲劳症状量表 (MFSI) 测量癌症相关疲劳；在相同的时间点评估对照。重复测量混合效应模型评估疲劳与糖尿病之间的关联，控制癌症（是/否）、体重指数、运动和吸烟习惯、基线焦虑和抑郁症状、更年期状况、婚姻状况、种族和教育。在 439 名患者和 235 名对照者（52.8±10.5 岁）中，患者的糖尿病患病率是对照者的两倍（11.6% vs. 6.8%）。在基线时，糖尿病与更严重的疲劳相关（4.1±1.7分，p=0.017）。此外，在整个研究期间，所有参与者（5.2±1.9分，p=0.008）和单独患者（4.5±2.0，p=0.023）中，糖尿病与具有临床意义的更严重疲劳相关。对于患者的 MFSI 子域，糖尿病与较差的一般状况 (p=0.005) 和精神疲劳 (p=0.026) 相关。与对照组相比，乳腺癌女性的糖尿病患病率是对照组的两倍，并且糖尿病与化疗前后以及化疗后 6 个月患者更严重的癌症相关疲劳有关。针对糖尿病管理的干预措施也可能有助于解决化疗期间与癌症相关的疲劳。
To quantify the relationship between diabetes and fatigue from pre-chemotherapy to 6 months post-chemotherapy for women with breast cancer compared to women without a history of cancer (controls). This was a secondary analysis from a nationwide prospective longitudinal study of female patients with breast cancer undergoing chemotherapy and controls. Diabetes diagnosis (yes/no) was obtained at baseline, and cancer-related fatigue was measured using the Multidimensional Fatigue Symptom Inventory (MFSI) pre-, post-, and 6-months post-chemotherapy in patients; controls were assessed at equivalent time points. Repeated measures mixed effects models estimated the association between fatigue and diabetes controlling for cancer (yes/no), body mass index, exercise and smoking habits, baseline anxiety and depressive symptoms, menopausal status, marital status, race, and education. Among 439 patients and 235 controls (52.8±10.5 years old), diabetes was twice as prevalent among patients as controls (11.6% vs. 6.8%). At baseline, diabetes was associated with worse fatigue (4.1±1.7 points, p=0.017). Also, diabetes was associated with clinically meaningful worse fatigue throughout the study period among all participants (5.2±1.9 points, p=0.008) and patients alone (4.5±2.0, p=0.023). For the MFSI subdomains among patients, diabetes was associated with worse general (p=0.005) and mental fatigue (p=0.026). Diabetes was twice as prevalent in women with breast cancer compared to controls, and diabetes was associated with more severe cancer-related fatigue in patients before and after chemotherapy and at 6 months post-chemotherapy. Interventions that address diabetes management may also help address cancer-related fatigue during chemotherapy treatment.
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影响因子：
3.1
作者：
Saligan, Leorey N.;Olson, Karin;Filler, Kristin;Larkin, David;Cramp, Fiona;Sriram, Yennu;Escalante, Carmen P.;del Giglio, Auro;Kober, Kord M.;Kamath, Jayesh;Palesh, Oxana;Mustian, Karen
通讯作者：
Mustian, Karen
影响因子：
3.7
作者：
Jones, Jennifer M.;Olson, Karin;Howell, Doris
通讯作者：
Howell, Doris
一项观察性研究，检查接受新辅助或辅助化学疗法的乳腺癌患者的代谢综合征成分变化。
影响因子：
6.2
作者：
Dieli-Conwright CM;Wong L;Waliany S;Bernstein L;Salehian B;Mortimer JE
通讯作者：
Mortimer JE
DOI：
10.1037/hea0000652
发表时间：
2018-11
期刊：
Health psychology : official journal of the Division of Health Psychology, American Psychological Association
影响因子：
--
作者：
Bower JE;Wiley J;Petersen L;Irwin MR;Cole SW;Ganz PA
通讯作者：
Ganz PA
影响因子：
1.8
作者：
Hershey DS
通讯作者：
Hershey DS