The biology of cancer-related fatigue: a review of the literature.
The biology of cancer-related fatigue: a review of the literature.
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DOI：
10.1007/s00520-015-2763-0
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发表时间：
2015-08
影响因子：
3.1
通讯作者：
Mustian, Karen
中科院分区：
文献类型：
--
作者：
Saligan, Leorey N.;Olson, Karin;Filler, Kristin;Larkin, David;Cramp, Fiona;Sriram, Yennu;Escalante, Carmen P.;del Giglio, Auro;Kober, Kord M.;Kamath, Jayesh;Palesh, Oxana;Mustian, Karen
了解癌症相关性疲劳（CRF）的病因对于确定目标以开发减轻CRF负担的治疗方法至关重要。本系统综述的目的是扩展国家癌症研究所CRF工作组的初步工作，以了解CRF生物学的科学现状。具体而言，评估研究生物标志物与CRF之间关系的研究，并建立CRF的病因学模型，以指导研究人员探索途径或研究治疗靶点。本综述由多国协会癌症疲劳支持治疗研究组-生物标志物工作组完成。最初的搜索使用了三个术语（生物标志物、疲劳、癌症），产生了11129篇文章。除去重复项后，还剩下7175篇。题目的关键词是“癌症”和“疲劳”，共有3811篇文章。排除2010年以前发表的文章和样本<50的文章，留下75篇全文综述。在75篇文章中，25篇因未调查生物标志物与CRF的关联而被进一步排除。在回顾的47篇文章中，25篇是横断面研究，22篇是纵向研究。不到一半（44%）是最近发表的（2010-2013）。几乎一半（46%）的研究对象是乳腺癌患者。大多数研究使用自我报告问卷来评估疲劳，只有两项研究使用临床参数来测量疲劳。本综述的研究结果表明，CRF与免疫/炎症、代谢、神经内分泌和遗传生物标志物有关。我们还发现了知识上的差距，并为未来的研究提出了建议。
Understanding the etiology of cancer-related fatigue (CRF) is critical to identify targets to develop therapies to reduce CRF burden. The goal of this systematic review was to expand on the initial work by the National Cancer Institute CRF Working Group to understand the state of the science of the biology of CRF. Specifically, to evaluate studies that examined the relationships between biomarkers and CRF, and to develop an etiologic model of CRF to guide researchers on pathways to explore or therapeutic targets to investigate. This review was completed by the Multinational Association of Supportive Care in Cancer Fatigue Study Group – Biomarker Working Group. The initial search used three terms (biomarkers, fatigue, cancer), which yielded 11,129 articles. After removing duplicates, 7,175 articles remained. Titles were assessed for the keywords, “cancer” and “fatigue” resulting in 3,811 articles. Articles published before 2010 and those with samples <50 were excluded, leaving 75 articles for full-text review. Of the 75 articles, 25 were further excluded for not investigating the associations of biomarkers and CRF. Of the 47 articles reviewed, 25 were cross-sectional and 22 were longitudinal studies. Less than half (44%) were published recently (2010-2013). Almost half (46%) enrolled breast cancer participants. A majority of studies assessed fatigue using self-report questionnaires, and only two studies used clinical parameters to measure fatigue. The findings from this review suggest that CRF is linked to immune/inflammatory, metabolic, neuroendocrine, and genetic biomarkers. We also identified gaps in knowledge and made recommendations for future research.
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DOI：
10.1016/j.bbacli.2014.04.001
发表时间：
2014-06-01
期刊：
BBA clinical
影响因子：
--
作者：
Filler, Kristin;Lyon, Debra;Bennett, James;McCain, Nancy;Elswick, Ronald;Lukkahatai, Nada;Saligan, Leorey N
通讯作者：
Saligan, Leorey N
影响因子：
45.3
作者：
Bower, Julienne E.;Ganz, Patricia A.;Cole, Steven W.
通讯作者：
Cole, Steven W.
影响因子：
1.9
作者：
Gélinas, C;Fillion, L
通讯作者：
Fillion, L
影响因子：
15.1
作者：
Fagundes, Christopher P.;Glaser, Ronald;Kiecolt-Glaser, Janice K.
通讯作者：
Kiecolt-Glaser, Janice K.
影响因子：
3.7
作者：
Fagundes, Christopher P.;Murray, David M.;Hwang, Beom Seuk;Gouin, Jean-Philippe;Thayer, Julian F.;Sollers, John J., III;Shapiro, Charles L.;Malarkey, William B.;Kiecolt-Glaser, Janice K.
通讯作者：
Kiecolt-Glaser, Janice K.