Diabetes is associated with increased risk for in-hospital mortality in patients with COVID-19: a systematic review and meta-analysis comprising 18,506 patients.
Diabetes is associated with increased risk for in-hospital mortality in patients with COVID-19: a systematic review and meta-analysis comprising 18,506 patients.
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糖尿病与COVID-19患者住院死亡风险增加相关：一项包括18，506例患者的系统性综述和荟萃分析
DOI：
10.1007/s42000-020-00246-2
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发表时间：
2021-06
期刊：
影响因子：
--
通讯作者：
Kokkinidis DG
中科院分区：
文献类型：
--
作者：
Palaiodimos L;Chamorro-Pareja N;Karamanis D;Li W;Zavras PD;Chang KM;Mathias P;Kokkinidis DG
在糖尿病患者中，传染病更加频繁，并可能与更糟糕的结局相关。这项研究的目的是对报道糖尿病对新冠肺炎住院患者死亡率影响的现有观察性研究进行系统回顾和荟萃分析。对Medline、Embase、Google Scholar和MedRxiv数据库进行了审查，以确定符合条件的研究。采用随机效应模型Meta分析，用I2评价异质性。住院死亡率被定义为终点。进行敏感度分析、亚组分析和元回归分析。共有18,506名患者被纳入这项荟萃分析(3713名糖尿病患者和14,793名非糖尿病患者)。与非糖尿病患者相比，糖尿病患者的死亡风险更高(OR 1.65；95%CI 1.35~1.96；I2 77.4%)。异质性较强。对所有重要的协变量进行了研究水平的Meta回归分析，没有发现协变量与死亡率之间存在显著的交互作用。这项荟萃分析显示，与非糖尿病患者相比，服用新冠肺炎的糖尿病患者死亡的可能性似乎更高。需要进一步的研究来评估这种关联是否独立，以及调查在感染新冠肺炎之前适当的血糖控制所起的作用。本文的在线版本(10.1007/s42000-02020-2)包含补充材料，可供授权用户使用。
Infectious diseases are more frequent and can be associated with worse outcomes in patients with diabetes. The aim of this study was to systematically review and conduct a meta-analysis of the available observational studies reporting the effect of diabetes on mortality among hospitalized patients with COVID-19. The Medline, Embase, Google Scholar, and medRxiv databases were reviewed for identification of eligible studies. A random effects model meta-analysis was used, and I2 was utilized to assess the heterogeneity. In-hospital mortality was defined as the endpoint. Sensitivity, subgroup, and meta-regression analyses were performed. A total of 18,506 patients were included in this meta-analysis (3713 diabetics and 14,793 non-diabetics). Patients with diabetes were associated with a higher risk of death compared with patients without diabetes (OR 1.65; 95% CI 1.35–1.96; I2 77.4%). The heterogeneity was high. A study-level meta-regression analysis was performed for all the important covariates, and no significant interactions were found between the covariates and the outcome of mortality. This meta-analysis shows that that the likelihood of death seems to be higher in diabetic patients hospitalized with COVID-19 compared with non-diabetic patients. Further studies are needed to assess whether this association is independent or not, as well as to investigate the role of adequate glycemic control prior to infection with COVID-19. The online version of this article (10.1007/s42000-020-00246-2) contains supplementary material, which is available to authorized users.
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影响因子：
5
作者：
Bode, Bruce;Garrett, Valerie;Klonoff, David C.
通讯作者：
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影响因子：
16.2
作者：
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DOI：
10.1136/bmj.b2535
发表时间：
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期刊：
BMJ (Clinical research ed.)
影响因子：
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作者：
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作者：
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影响因子：
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作者：
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通讯作者：
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