A Role for the Periaqueductal Gray in Switching Adaptive Behavioral Responses
A Role for the Periaqueductal Gray in Switching Adaptive Behavioral Responses
复制标题
导水管周围灰质在切换适应性行为反应中的作用
作者：
M. H. Sukikara;S. Mota;M. Baldo;L. Felicio;N. Canteras
先前的研究表明，在有吗啡经验的母鼠中，吻侧侧导水管周围灰质（PAG）在低剂量吗啡诱导的母性行为抑制中起作用。在本研究中，我们首次发现位于PAG特定区域的单侧NMDA病变阻止了吗啡诱导的母体行为抑制。正如先前Fos关于PAG的数据所表明的那样，在吗啡处理过的水坝中，掠食性狩猎似乎是取代母性行为的可能选择。通过仅用活蟑螂测试盐水和吗啡处理过的水坝，我们目前已经表明吗啡挑战增加了昆虫狩猎。此外，吗啡和盐处理的水坝也被观察到在一个有幼崽和蟑螂的环境中。虽然大多数盐水处理的动物表现出积极的哺乳行为，只是偶尔表现出捕食昆虫的行为，但所有吗啡处理的动物都无视小强，贪婪地追逐和捕捉蟑螂。我们接下来质疑吻侧PAG是否会参与这种行为转换。我们的研究结果表明，喙侧侧PAG单侧病变，而PAG其他部分没有，部分损害了掠食性狩猎，并恢复了部分母性反应。此外，吻侧侧PAG的双侧病变在抑制昆虫捕食和恢复母性行为方面产生了更显着的作用。目前的研究结果无可争议地表明，在吗啡处理的坝中，吻侧侧PAG影响从母性行为到狩猎行为的转变，从而支持了PAG在选择适应性行为反应中的先前未被怀疑的作用。
Previous studies suggested a role for the rostral lateral periaqueductal gray (PAG) in the inhibition of maternal behavior induced by low doses of morphine in dams with previous morphine experience. In the present study, we first showed that unilateral NMDA lesions placed in this particular PAG region prevented the morphine-induced inhibition of maternal behavior in previously morphine-sensitized dams. As suggested by previous Fos data on the PAG, predatory hunting appears as a likely candidate to replace maternal behavior in the morphine-treated dams. By testing saline- and morphine-treated dams with live cockroaches only, we have presently shown that morphine challenge increased insect hunting. Moreover, morphine- and saline-treated dams were also observed in an environment containing pups and roaches. Although most of the saline-treated animals displayed active nursing and only occasionally presented insect hunting, all of the morphine-treated animals ignored the pups and avidly pursued and caught the roaches. We next questioned whether the rostral lateral PAG would be involved in this behavioral switch. Our results showed that unilateral lesions of the rostral lateral PAG, but not other parts of the PAG, partially impaired predatory hunting and restored part of the maternal response. Moreover, bilateral lesions of the rostral lateral PAG produced even more dramatic effects in inhibiting insect hunting and restoring maternal behavior. The present findings indisputably show that the rostral lateral PAG influences switching from maternal to hunting behavior in morphine-treated dams, thus supporting a previously unsuspected role for the PAG in selecting adaptive behavioral responses.
产前吗啡暴露对母亲行为的长期影响不同于直接长期吗啡治疗的影响。
影响因子：
2.2
作者：
Slamberová,Romana;Bar,Noffar;Vathy,Ilona
通讯作者：
Vathy,Ilona