Peripodial adherens junctions regulate Ajuba-Yorkie signaling to preserve fly eye morphology.
Peripodial adherens junctions regulate Ajuba-Yorkie signaling to preserve fly eye morphology.
复制标题
周围的粘附连接器调节Ajuba-yorkie信号传导，以保持苍蝇的眼睛形态。
作者：
The Drosophila eye develops from the larval eye disc, a flattened vesicle comprised of continuous retinal and peripodial epithelia (PE). The PE is an epithelium that plays a supporting role in retinal neurogenesis, but gives rise to cuticle in the adult. We report here that the PE is also necessary to preserve the morphology of the retinal epithelium. Depletion of the adherens junction (AJ) components β-Catenin (β-Cat), DE-Cadherin or α-Catenin from the PE leads to altered disc morphology, characterized by retinal displacement (RDis); so too does loss of the Ajuba protein Jub, an AJ-associated regulator of the transcriptional coactivator Yorkie (Yki). Restoring AJs or overexpressing Yki in β-Cat deficient PE results in suppression of RDis. Additional suppressors of AJ-dependent RDis include knockdown of Rho kinase (Rok) and Dystrophin (Dys). Furthermore, knockdown of βPS integrin (Mys) from the PE results in RDis, while overexpression of Mys can suppress RDis induced by the loss of β-Cat. We thus propose that AJ-Jub-Yki signaling in PE cells regulates PE cell contractile properties and/or attachment to the extracellular matrix to promote normal eye disc morphology. Summary: Adherens junctions in the peripodial epithelium of the Drosophila eye disc promote normal morphology of the retinal epithelium and fly eye via a Jub-Wts-Yki-ECM signaling axis.
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影响因子：
5.3
作者：
Jagannathan R;Schimizzi GV;Zhang K;Loza AJ;Yabuta N;Nojima H;Longmore GD
通讯作者：
Longmore GD
影响因子：
8.8
作者：
Chen, Dong-Yuan;Crest, Justin;Bilder, David
通讯作者：
Bilder, David
DOI：
10.1016/j.cub.2010.02.035
发表时间：
2010-04-13
期刊：
Current biology : CB
影响因子：
--
作者：
Das Thakur M;Feng Y;Jagannathan R;Seppa MJ;Skeath JB;Longmore GD
通讯作者：
Longmore GD
影响因子：
4.6
作者：
Baker, Luke R.;Weasner, Bonnie M.;Kumar, Justin P.
通讯作者：
Kumar, Justin P.
影响因子：
4
作者：
Ibar, Consuelo;Kirichenko, Elmira;Irvine, Kenneth D.
通讯作者：
Irvine, Kenneth D.