The Association of Hypertension With the Severity of and Mortality From the COVID-19 in the Early Stage of the Epidemic in Wuhan, China: A Multicenter Retrospective Cohort Study.
The Association of Hypertension With the Severity of and Mortality From the COVID-19 in the Early Stage of the Epidemic in Wuhan, China: A Multicenter Retrospective Cohort Study.
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在中国武汉的早期，高血压与COVID-19的严重程度和死亡率的关联：一项多中心回顾性队列研究。
DOI：
10.3389/fmed.2021.623608
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发表时间：
2021
影响因子：
3.9
通讯作者：
Cao J
中科院分区：
文献类型：
--
作者：
Mubarik S;Liu X;Eshak ES;Liu K;Liu Q;Wang F;Shi F;Wen H;Bai J;Yu C;Cao J
背景：高血压可能影响COVID-19疾病的预后。我们分析了高血压与非高血压死亡COVID-19患者的疾病严重程度和死亡率相关的流行病学和临床特征。研究方法：我们纳入了2020年12月1日至2月24日期间在武汉超过200家医疗机构收治的所有实验室确诊的COVID-19死亡患者。在年龄和性别倾向评分匹配（PS）前后，分别使用Kaplan-Meier生存分析、logistic回归和考克斯比例回归评估了伴和不伴高血压的COVID-19患者的中位生存时间、高血压与疾病严重程度的相关性以及与按高血压状态分层的COVID-19死亡率相关的风险因素。结果：在研究的1，833名COVID-19患者中，高血压患病率为40.5%。高血压患者比非高血压患者更有可能患上严重的COVID-19疾病; PS匹配的多变量校正比值比（95%CI）为2.44（1.77-3.08）。高血压组中位生存期较非高血压组短3-5天。与非高血压组相比，高血压组的COVID-19死亡风险增加了2倍; PS匹配的多变量调整风险比（HR）= 2.04（1.61-2.72），中度与轻度COVID-19疾病中COVID-19死亡风险的显著增加仅限于高血压患者。此外，与非高血压患者相比，高血压患者的基础慢性病史和数量、职业和居住地与COVID-19死亡率的相关性更强。结论：高血压与COVID-19疾病的严重程度和死亡率相关。
Background: Hypertension may affect the prognosis of COVID-19 illness. We analyzed the epidemiological and clinical characteristics associated with the disease severity and mortality in hypertensive vs. non-hypertensive deceased COVID-19 patients. Methods: We included all the deceased patients with laboratory-confirmed COVID-19 admitted to >200 health facilities in Wuhan between December 1 and February 24, 2020. The median survival time in COVID-19 patients with and without hypertension, the association of hypertension with the disease severity, and the risk factors associated with the COVID-19 mortality stratified by the hypertension status were assessed using the Kaplan-Meier survival analysis, logistic regression, and Cox proportional regression, respectively before and after the propensity score-matching (PS) for age and sex. Results: The prevalence of hypertension in the studied 1,833 COVID-19 patients was 40.5%. Patients with hypertension were more likely to have severe COVID-19 illness than patients without hypertension; the PS-matched multivariable-adjusted odds ratio (95% CI) was 2.44 (1.77–3.08). Moreover, the median survival time in the hypertension group was 3–5 days shorter than the non-hypertension group. There was a 2-fold increased risk of COVID-19 mortality in the hypertension group compared with the non-hypertension group; the PS-matched multivariable-adjusted hazard ratio (HR) = 2.04 (1.61–2.72), and the significant increased risk of COVID-19 mortality in the moderate vs. mild COVID-19 illness was confined to patients with hypertension. Additionally, the history and the number of underlying chronic diseases, occupation, and residential location showed stronger associations with the COVID-19 mortality among patients with hypertension than patients without hypertension. Conclusion: Hypertension was associated with the severity and mortality of COVID-19 illness.
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DOI：
10.1038/s41581-019-0244-2
发表时间：
2020-04
期刊：
Nature reviews. Nephrology
影响因子：
--
作者：
Mills KT;Stefanescu A;He J
通讯作者：
He J
影响因子：
28.3
作者：
Gorbalenya, Alexander E.;Baker, Susan C.;Ziebuhr, John
通讯作者：
Ziebuhr, John
影响因子：
2
作者：
Austin, Peter C.
通讯作者：
Austin, Peter C.
影响因子：
24
作者：
Li, Juyi;Wang, Xiufang;Deng, Aiping
通讯作者：
Deng, Aiping
影响因子：
3.7
作者：
Javanmardi F;Keshavarzi A;Akbari A;Emami A;Pirbonyeh N
通讯作者：
Pirbonyeh N