The unrecognized burden of cardiovascular risk factors in women newly diagnosed with endometrial cancer: A prospective case control study.
The unrecognized burden of cardiovascular risk factors in women newly diagnosed with endometrial cancer: A prospective case control study.
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DOI：
10.1016/j.ygyno.2017.11.019
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发表时间：
2018-01
影响因子：
4.7
通讯作者：
Crosbie EJ
中科院分区：
文献类型：
--
作者：
Kitson SJ;Lindsay J;Sivalingam VN;Lunt M;Ryan NAJ;Edmondson RJ;Rutter MK;Crosbie EJ
心血管疾病的风险是在一项前瞻性研究中测量的150例EC患者和746名对照。EC患者的CVD危险因素明显多于其他女性。大多数CVD风险因素未被认识或未得到充分治疗。EC患者的10年CVD风险（QRISK 2）显著高于对照组。识别和治疗CVD危险因素可以改善EC幸存者的结局。心血管疾病是子宫内膜癌幸存者死亡的主要原因。本研究的目的是确定新诊断为子宫内膜癌的妇女是否比普通人群有更高的心血管危险因素患病率。在英格兰西北部接受子宫内膜癌初级治疗的150名连续女性中，以及来自2014年英格兰健康调查的746名年龄和种族匹配的对照女性中，测量了充分治疗和未识别/未充分治疗的心血管风险因素的患病率以及相应的10年心血管风险QRISK 2评分。患有子宫内膜癌的女性肥胖比例较高（BMI ≥ 30的比例为60.7%比32.4%，p < 0.0001），并且存在大量未被认识到且治疗不充分的心血管危险因素。与对照组相比，子宫内膜癌患者高血糖发生率更高（57.2% vs. 11.5%，p < 0.0001），总胆固醇：高密度脂蛋白胆固醇比值> 4.5（26.7% vs. 13.7%，p < 0.0001），更可能有三个或更多的心血管危险因素（22% vs. 6%，p < 0.0001）。这相当于更高的10年心血管风险（中位数QRISK 2评分12.6% vs. 8.8%，p < 0.0001）。风险因素的优化对病例的绝对心血管疾病风险的影响大于对照组（QRISK 2评分降低1.8% vs. 0.7%）。接受子宫内膜癌初级治疗的妇女比没有这种疾病的妇女有更高的心血管危险因素的患病率。早期识别和治疗这些危险因素可以改善子宫内膜癌幸存者的预后。
CVD risk was measured in a prospective study of 150 EC patients and 746 controls. EC patients had significantly more CVD risk factors than other women. Most CVD risk factors were either unrecognized or inadequately treated. EC patients had a significantly higher 10-year risk of CVD (QRISK2) than controls. Identifying and treating CVD risk factors could improve outcomes for EC survivors. Cardiovascular disease is a major cause of death in endometrial cancer survivors. The aim of this study was to determine whether women newly diagnosed with endometrial cancer have a higher prevalence of cardiovascular risk factors than the general population. The prevalence of adequately treated and unrecognized/inadequately treated cardiovascular risk factors and the corresponding 10-year cardiovascular risk by QRISK2 score was measured in 150 consecutive women undergoing primary treatment for endometrioid endometrial cancer in the North West of England, and 746 age and ethnicity-matched control women from the Health Survey for England 2014. Women with endometrial cancer had higher proportions of obesity (BMI ≥ 30 60.7% vs. 32.4%, p < 0.0001) and a preponderance of unrecognized and inadequately treated cardiovascular risk factors. Compared with controls, endometrial cancer cases had a higher prevalence of incident hyperglycemia (57.2% vs. 11.5%, p < 0.0001), total: HDL cholesterol ratio > 4.5 (26.7% vs. 13.7%, p < 0.0001), and were more likely to have three or more cardiovascular risk factors (22% vs. 6%, p < 0.0001). This equates to a higher 10-year cardiovascular risk (median QRISK2 score 12.6% vs. 8.8%, p < 0.0001). Optimization of risk factors would have a greater impact on absolute cardiovascular disease risk for cases than controls (QRISK2 score reduction 1.8% vs. 0.7%). Women undergoing primary treatment for endometrial cancer have a higher prevalence of cardiovascular risk factors than women without the disease. Early identification and treatment of these risk factors could improve outcomes for endometrial cancer survivors.
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影响因子：
105.7
作者：
Hippisley-Cox, Julia;Coupland, Carol;Brindle, Peter
通讯作者：
Brindle, Peter
影响因子：
9.8
作者：
Burzawa JK;Schmeler KM;Soliman PT;Meyer LA;Bevers MW;Pustilnik TL;Anderson ML;Ramondetta LM;Tortolero-Luna G;Urbauer DL;Chang S;Gershenson DM;Brown J;Lu KH
通讯作者：
Lu KH
DOI：
10.1111/1471-0528.13684
发表时间：
2016-01-01
影响因子：
5.8
作者：
Laskey, R. A.;McCarroll, M. L.;von Gruenigen, V. E.
通讯作者：
von Gruenigen, V. E.
DOI：
10.1111/bjd.14557
发表时间：
2016-08-01
期刊：
The British journal of dermatology
影响因子：
--
作者：
Rutter, M K;Kane, K;Griffiths, C E M
通讯作者：
Griffiths, C E M
影响因子：
--
作者：
Wing, Rena R.;Bahnson, Judy L.;Bray, George A.;Clark, Jeanne M.;Coday, Mace;Egan, Caitlin;Espeland, Mark A.;Foreyt, John P.;Gregg, Edward W.;Goldman, Valerie;Haffner, Steven M.;Hazuda, Helen;Hill, James O.;Horton, Edward S.;Hubbard, Van S.;Jakicic, John;Jeffery, Robert W.;Johnson, Karen C.;Kahn, Steven;Killean, Tina;Kitabchi, Abbas E.;Lewis, Cora E.;Manus, Cathy;Maschak-Carey, Barbara J.;Michaels, Sara;Montez, Maria;Montgomery, Brenda;Nathan, David M.;Patricio, Jennifer;Peters, Anne;Pi-Sunyer, Xavier;Pownall, Henry;Reboussin, David;Rejeski, Jack;Rubin, Richard;Safford, Monika;Skarphol, Tricia;Van Dorsten, Brent;Wadden, Thomas A.;Wagenknecht, Lynne;Wesche-Thobaben, Jacqueline;West, Delia S.;Williamson, Donald;Yanovski, Susan Z.
通讯作者：
Yanovski, Susan Z.