Prospective evaluation of insulin resistance among endometrial cancer patients.
Prospective evaluation of insulin resistance among endometrial cancer patients.
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DOI：
10.1016/j.ajog.2010.11.033
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发表时间：
2011-04
影响因子：
9.8
通讯作者：
Lu KH
中科院分区：
文献类型：
--
作者：
Burzawa JK;Schmeler KM;Soliman PT;Meyer LA;Bevers MW;Pustilnik TL;Anderson ML;Ramondetta LM;Tortolero-Luna G;Urbauer DL;Chang S;Gershenson DM;Brown J;Lu KH
肥胖和雌激素是子宫内膜癌的重要危险因素。虽然糖尿病也会增加风险，但人们对相关的胰岛素抵抗（IR）知之甚少。本研究的目的是确定新诊断的EC患者中IR的患病率。本研究前瞻性地纳入了2005-2008年间来自一个大城市县的EC患者。分析空腹血清葡萄糖和胰岛素水平。IR定义为糖尿病史或QUICKI[1/（对数空腹胰岛素+对数空腹血糖）]值<0.357。在99例患者中，30例出现糖尿病，另外36例发现QUICKI异常。IR风险增加与较高的BMI （p<0.001）、较低的社会经济地位（p=0.007）和零生育（p=0.029）显著相关。IR在子宫内膜癌患者中非常普遍，包括非肥胖女性。除了肥胖之外，更好地描述代谢风险可能为未来有针对性的癌症预防提供途径。
Obesity and estrogen are strong risk factors for endometrial cancer (EC). While diabetes also increases risk, little is known about related insulin resistance (IR). The purpose of this study was to determine the prevalence of IR in newly diagnosed EC patients. EC patients from a large, metropolitan county were prospectively enrolled from 2005–2008. Fasting serum was analyzed for glucose and insulin. IR was defined as a history of diabetes or a QUICKI [1/(log fasting insulin + log fasting glucose)] value of <0.357. Among 99 patients, diabetes was present in 30, and an abnormal QUICKI was found in 36 additional patients. Increased risk of IR was significantly associated with higher BMI (p<0.001), lower socioeconomic status (p=0.007), and nulliparity (p=0.029). IR was highly prevalent in endometrial cancer patients, including non-obese women. Better characterization of metabolic risks in addition to obesity may provide avenues for targeted cancer prevention in the future.
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DOI：
10.1016/0002-9378(91)90047-u
发表时间：
1991-12-01
影响因子：
9.8
作者：
NAGAMANI, M;STUART, CA;DOHERTY, MG
通讯作者：
DOHERTY, MG
影响因子：
5.8
作者：
Dal Maso, L;Augustin, LSA;La Vecchia, C
通讯作者：
La Vecchia, C
影响因子：
9.8
作者：
Zhang, Qian;Shen, Qi;Lu, Karen H.
通讯作者：
Lu, Karen H.
DOI：
10.1093/jnci/88.16.1127
发表时间：
1996-08-21
期刊：
JOURNAL OF THE NATIONAL CANCER INSTITUTE
影响因子：
--
作者：
Potischman, N;Hoover, RN;Lurain, JR
通讯作者：
Lurain, JR
影响因子：
7.7
作者：
Chen, H;Sullivan, G;Quon, MJ
通讯作者：
Quon, MJ