Human-specific evolutionary changes in the biology of siglecs.
Human-specific evolutionary changes in the biology of siglecs.
复制标题
siglecs 生物学中人类特有的进化变化。
DOI：
10.1007/978-3-319-11280-0_1
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发表时间：
2015
影响因子：
--
通讯作者：
Varki,Ajit
中科院分区：
文献类型：
--
作者：
Schwarz,Flavio;Fong,JerryJ;Varki,Ajit
Siglecs are a family of sialic acid-recognizing immunoglobulin-like lectins that exhibit multiple human-specific and human-universal differences, including changes in binding specificity (Siglec-5, -7, -9, -11, -12 and 14); changes in expression pattern (Siglec-1, -5, -6, and -11); gene conversion (SIGLEC11); gene deletion (SIGLEC13) and pseudogenization (SIGLEC17). Human-unique pseudogenes ofSIGLEC12,SIGLEC14andSIGLEC16are also polymorphic within human populations, suggesting ongoing selection on this family of genes. The apparently higher concentration ofSIGLECchanges in the human lineage may have been selected by interactions with pathogens binding Siglecs, and/or as compensatory responses to the loss of the sialic acidN-glycolylneuraminic acid (Neu5Gc) in humans. Human-specific Siglec changes of particular interest include expression of Siglec-11 in brain microglia, expression of Siglec-6 on placental trophoblast, suppression of Siglec-5 expression on adaptive immune cells, new expression of Siglec-5 on amniotic epithelium, and elimination of Siglec-13 and -17 from innate immune cells. The Siglec-13 and -17 inactivation events fixed in the ancestral population shortly before the common ancestor of modern humans 100–200 thousand years ago, and resurrected Siglec-13 and -17 gene products bind potentially lethal pathogens of infants. While such pathogens may have contributed to population bottlenecks in human evolution, the resulting changes in sialic acid biology may also have altered multiple systems where sialic acid and Siglecs have endogenous roles. Thus, genes associated with sialic acid biology appear to be a “hot spot” of genetic and physiological change during human evolution, with implications for human origins, and for uniquely human features in health and disease.
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影响因子：
4.3
作者：
E. B. D. Brinkman-van der Linden;Nancy Hurtado-Ziola;T. Hayakawa;Lisa Wiggleton;K. Benirschke;A. Varki;N. Varki
通讯作者：
E. B. D. Brinkman-van der Linden;Nancy Hurtado-Ziola;T. Hayakawa;Lisa Wiggleton;K. Benirschke;A. Varki;N. Varki
影响因子：
29.7
作者：
Pillai S;Netravali IA;Cariappa A;Mattoo H
通讯作者：
Mattoo H
人类和黑猩猩卵巢基质细胞表达 Siglec-11，具有独特的人类配体：对人类卵巢生理学和病理学的影响。
影响因子：
4.3
作者：
Wang,Xiaoxia;Chow,Renee;Deng,Liwen;Anderson,Dan;Weidner,Noel;Godwin,AndrewK;Bewtra,Chanda;Zlotnik,Albert;Bui,Jack;Varki,Ajit;Varki,Nissi
通讯作者：
Varki,Nissi
DOI：
10.1073/pnas.0914634107
发表时间：
2010-05-11
影响因子：
11.1
作者：
Varki, Ajit
通讯作者：
Varki, Ajit
S2V 的鉴定和表征，S2V 是一种新型推定 Siglec，包含两个 V 组 Ig 样结构域并招募蛋白酪氨酸磷酸酶 SHP*
影响因子：
4.8
作者：
Zhenbao Yu;Ching;M. Maoui;D. Banville;S. Shen
通讯作者：
S. Shen