The timing of pediatric epilepsy syndromes: What are the developmental triggers?
The timing of pediatric epilepsy syndromes: What are the developmental triggers?
复制标题
小儿癫痫综合征的发生时间：发育触发因素是什么？
DOI：
--
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发表时间：
2013
影响因子：
5.2
通讯作者：
J. Paolicchi
中科院分区：
文献类型：
--
作者：
J. Paolicchi
儿童癫痫的特点是具有特定发育触发因素的多种癫痫综合征。它们在发育的关键时期自发地启动，也可以自发地缓解。伴随的神经认知障碍通常是癫痫综合征特有的。婴儿或癫痫痉挛在生命的第一年有一个非常特定的发育窗口。在癫痫发作之前，发育停滞是常见的。通过PET扫描，痉挛发生的神经学通路已被确定为脑干和基底神经节中多巴胺能和GABA能神经递质系统的发育异常。儿童失神性癫痫（CAE）和良性中央颞叶癫痫综合征（BECTS）都是已知的遗传性癫痫综合征;它们在儿童期发作，青春期缓解。在CAE中，特定钙通道在关键发育阶段的干扰导致丘脑皮质同步性的异常破坏。类似地，大脑发育、成熟和易感基因之间复杂的相互作用是BECTS癫痫发作和神经认知缺陷的基础。
Pediatric epilepsy is characterized by multiple epilepsy syndromes with specific developmental triggers. They initiate spontaneously at critical periods of development and can just as spontaneously remit. Accompanying neurocognitive disabilities are often specific to the epileptic syndrome. Infantile or epileptic spasms have a very specific developmental window in the first year of life. Preceding the epilepsy, developmental arrest is common. The neurologic pathways underlying the development of spasms have been identified through PET scans as developmental abnormalities of serotonergic and GABAergic neurotransmitter systems in the brain stem and basal ganglia. Childhood absence epilepsy (CAE) and benign centrotemporal epilepsy syndrome (BECTS) are both known genetic epilepsy syndromes; they have a discrete onset in childhood with remission by puberty. In CAE, disturbances of specific calcium channels at key developmental stages lead to aberrant disruption of thalamocortical synchrony. Similarly, a complex interplay between brain development, maturation, and susceptibility genes underlies the seizures and the neurocognitive deficits of BECTS.
DOI：
10.1056/nejmoa0902014
发表时间：
2010-03-04
期刊：
The New England journal of medicine
影响因子：
--
作者：
Glauser TA;Cnaan A;Shinnar S;Hirtz DG;Dlugos D;Masur D;Clark PO;Capparelli EV;Adamson PC;Childhood Absence Epilepsy Study Group
通讯作者：
Childhood Absence Epilepsy Study Group
影响因子：
56.9
作者：
CHUGANI, HT;PHELPS, ME
通讯作者：
PHELPS, ME
影响因子：
14.5
作者：
Marsh, Eric;Fulp, Carl;Golden, Jeffrey A.
通讯作者：
Golden, Jeffrey A.