Establishment of an interleukin 2-dependent human T cell line from a patient with T cell chronic lymphocytic leukemia who is not infected with human T cell leukemia/lymphoma virus.
Establishment of an interleukin 2-dependent human T cell line from a patient with T cell chronic lymphocytic leukemia who is not infected with human T cell leukemia/lymphoma virus.
复制标题
从未感染人 T 细胞白血病/淋巴瘤病毒的 T 细胞慢性淋巴细胞白血病患者中建立白细胞介素 2 依赖性人 T 细胞系。
作者：
Toshiyuki Hori;T. Uchiyama;M. Tsudo;H. Umadome;H. Ohno;S. Fukuhara;K. Kita;H. Uchino
我们建立了一个白细胞介素2（IL-2）依赖的人T细胞系，试剂盒225，从患者的T细胞慢性淋巴细胞白血病（T-CLL）与OKT 3+，-T4+，-T8-表型。Southern印迹分析表明Kit 225不感染人T细胞白血病/淋巴瘤病毒（HTLV）I型或II型，可能来源于新鲜白血病细胞中的主要克隆。Kit 225细胞组成性表达大量IL 2受体，其生长完全依赖IL 2。维持对IL 2的反应性不需要其它刺激物，如凝集素或抗原.由于IL-2受体表达异常最初也见于新鲜白血病细胞中，用IL-2建立该细胞系表明IL-2介导的T细胞增殖参与了某些HTLV阴性T-CLL病例的白血病发生。
We established an interleukin 2 (IL-2)-dependent human T cell line, Kit 225, from a patient with T cell chronic lymphocytic leukemia (T-CLL) with OKT3+, -T4+, -T8- phenotype. Southern blot analysis showed that Kit 225 is not infected with human T cell leukemia/lymphoma virus (HTLV) type I or II, and is probably derived from the major clone in the fresh leukemic cells. Kit 225 cells express a large amount of IL 2 receptors constitutively and their growth is absolutely dependent on IL 2. No other stimuli, such as lectins or antigens, are required for maintaining the responsiveness to IL 2. As abnormal IL 2 receptor expression was also seen originally in the fresh leukemic cells, the establishment of this cell line with IL 2 suggests that IL 2-mediated T cell proliferation is involved in the leukemogenesis of some cases of HTLV-negative T-CLL.
恶性 Sézary 和 T-CLL 细胞上的表面抗原与成熟 T 细胞的表面抗原相对应。
影响因子：
20.3
作者：
Boumsell,L;Bernard,A;Reinherz,EL;Nadler,LM;Ritz,J;Coppin,H;Richard,Y;Dubertret,L;Valensi,F;Degos,L;Lemerle,J;Flandrin,G;Dausset,J;Schlossman,SF
通讯作者：
Schlossman,SF
影响因子：
56.9
作者：
CANTRELL, DA;SMITH, KA
通讯作者：
SMITH, KA