Immunization with glycoprotein subunits of respiratory syncytial virus to protect cotton rats against viral infection.
Immunization with glycoprotein subunits of respiratory syncytial virus to protect cotton rats against viral infection.
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免疫呼吸道合胞病毒糖蛋白亚基可保护棉鼠免受病毒感染。
DOI：
10.1093/infdis/155.6.1198
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发表时间：
1987
期刊：
影响因子：
--
通讯作者：
Jacob J. Schlesinger
中科院分区：
文献类型：
--
作者：
Edward E. Walsh;Caroline B. Hall;Michael Briselli;M. W. Brandriss;Jacob J. Schlesinger
采用棉花大鼠呼吸道合胞病毒感染模型，研究了病毒糖蛋白免疫。用纯化的附着蛋白(G)或融合蛋白(F)免疫的动物对呼吸道合胞病毒的攻击产生完全的肺部抵抗，但只有部分的鼻腔抵抗。针对G蛋白产生的抗体能中和病毒，而针对F蛋白产生的抗体能中和病毒并抑制感染细胞的融合。没有证据表明任何免疫组的肺部病理增强。
The cotton rat model of respiratory syncytial virus infection was used to study immunization with viral glycoproteins. Animals immunized with the purified attachment protein (G) or the fusion protein (F) developed complete pulmonary resistance, but only partial nasal resistance, to challenge with respiratory syncytial virus. Antibody produced to the G protein neutralized virus, whereas antibody to the F protein neutralized virus and also inhibited fusion of infected cells. There was no evidence of enhanced pulmonary pathology in any immunized group.
人呼吸道合胞病毒 10 种蛋白的表征：第四种包膜相关蛋白的鉴定。
影响因子：
5
作者：
Huang,YT;Collins,PL;Wertz,GW
通讯作者：
Wertz,GW
影响因子：
3.7
作者：
MERZ, DC;SCHEID, A;CHOPPIN, PW
通讯作者：
CHOPPIN, PW