Modulation of the cortical silent period elicited by single- and paired-pulse transcranial magnetic stimulation.
Modulation of the cortical silent period elicited by single- and paired-pulse transcranial magnetic stimulation.
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DOI：
10.1186/1471-2202-14-43
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发表时间：
2013-04-02
期刊：
影响因子：
2.4
通讯作者：
Tamaki H
中科院分区：
文献类型：
--
作者：
Kojima S;Onishi H;Sugawara K;Kirimoto H;Suzuki M;Tamaki H
经颅磁刺激（TMS）引起的皮层沉默期（CSP）受TMS强度变化的影响。有研究表明短间隔皮层内抑制（SICI）和皮层内易化（ICF）可缩短或延长CSP，但这些研究采用不同的TMS强度来调节运动诱发电位（MEP）的幅度。因此，目前尚不清楚CSP持续时间的变化是否是由TMS强度的变化或SICI和ICF引起的。本研究的目的是证实肌肉收缩和刺激强度对单脉冲TMS诱发的MEP幅度和CSP持续时间的影响，并阐明SICI和ICF对CSP持续时间的影响。在15例健康人右侧第一骨间背侧肌上检测经颅磁刺激诱发的运动诱发电位。首先，在四个肌肉收缩水平[10%，30%，50%和70%肌电图（EMG）]下，通过单脉冲TMS以100%主动运动阈值（AMT）的强度诱导MEP和CSP。接着，在10%EMG的肌肉收缩期间，通过七种TMS强度（100%、110%、120%、130%、140%、150%和160%AMT）诱导MEP和CSP。最后，在四个肌肉收缩水平（0%、10%、30%和50%EMG）下记录SICI和ICF。MEP振幅随肌肉收缩和刺激强度的增加而增加。然而，CSP持续时间没有不同的肌肉收缩水平，并延长与刺激强度的增加。与单脉冲TMS和ICF诱导的CSP相比，在所有肌肉收缩水平下，SICI缩短了CSP，而CSP持续时间与ICF没有显着变化。我们证实，CSP持续时间的影响TMS强度，但不是由肌肉收缩水平。本研究表明，SICI缩短了CSP，但ICF没有改变CSP。这些结果表明，在SICI后，CSP持续时间受到由条件性SICI刺激激活的抑制性中间神经元的活性的影响。
The cortical silent period (CSP) elicited by transcranial magnetic stimulation (TMS) is affected by changes in TMS intensity. Some studies have shown that CSP is shortened or prolonged by short-interval intracortical inhibition (SICI) and intracortical facilitation (ICF), Those studies, however, used different TMS intensities to adjust the amplitude of the motor evoked potential (MEP). Therefore, it is unclear whether changes in CSP duration are induced by changes in TMS intensities or by SICI and ICF. The purpose of this study was to confirm the effects of muscle contractions and stimulus intensities on MEP amplitude and the duration of CSP induced by single-pulse TMS and to clarify the effects of SICI and ICF on CSP duration. MEP evoked by TMS was detected from the right first dorsal interosseous muscle in 15 healthy subjects. First, MEP and CSP were induced by single-pulse TMS with an intensity of 100% active motor threshold (AMT) at four muscle contraction levels [10%, 30%, 50%, and 70% electromyogram (EMG)]. Next, MEP and CSP were induced by seven TMS intensities (100%, 110%, 120%, 130%, 140%, 150%, and 160% AMT) during muscle contraction of 10% EMG. Finally, SICI and ICF were recorded at the four muscle contraction levels (0%, 10%, 30%, and 50% EMG). MEP amplitudes increased with increases in muscle contraction and stimulus intensity. However, CSP duration did not differ at different muscle contraction levels and was prolonged with increases in stimulus intensity. CSP was shortened with SICI compared with CSP induced by single-pulse TMS and with ICF at all muscle contraction levels, whereas CSP duration was not significantly changed with ICF. We confirmed that CSP duration is affected by TMS intensity but not by the muscle contraction level. This study demonstrated that CSP is shortened with SICI, but it is not altered with ICF. These results indicate that after SICI, CSP duration is affected by the activity of inhibitory intermediate neurons that are activated by the conditioning SICI stimulus.
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