Postnatal Craniofacial Skeletal Development of Female C57BL/6NCrl Mice.
Postnatal Craniofacial Skeletal Development of Female C57BL/6NCrl Mice.
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雌性 C57BL/6NCrl 小鼠产后颅面骨骼发育
DOI：
10.3389/fphys.2017.00697
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发表时间：
2017
影响因子：
4
通讯作者：
Liu F
中科院分区：
文献类型：
--
作者：
Wei X;Thomas N;Hatch NE;Hu M;Liu F
颅面骨骼是一种复杂而独特的结构。其发育的扰动可导致颅面畸形和相关的发病率。我们预防或减轻颅面骨骼异常的能力至少部分取决于我们对颅面骨骼独特生理发育的理解。小鼠模型是研究颅面发育异常的重要工具。然而，文献中缺乏小鼠颅面骨骼发育的详细规范数据。在本报告中，我们采用高分辨率微计算机断层扫描（μCT）结合形态测量分析了雌性C57BL/6NCrl小鼠出生后第7天（P7）至第390天（P390）的颅面骨骼发育情况。我们的数据显示了雌性C57BL/6NCrl小鼠独特的颅面骨骼发育模式，并区分了早期和晚期颅面生长模式。此外，我们的数据记录了不同胚胎来源和骨化机制的各种颅面骨在出生后生长过程中骨参数（厚度、骨体积、骨体积/组织体积、骨矿物质密度和组织矿物质密度）的复杂性和差异性变化，强调了颅面骨发育的复杂性，为未来颅面骨的定量分析提供了参考标准。
The craniofacial skeleton is a complex and unique structure. The perturbation of its development can lead to craniofacial dysmorphology and associated morbidities. Our ability to prevent or mitigate craniofacial skeletal anomalies is at least partly dependent on our understanding of the unique physiological development of the craniofacial skeleton. Mouse models are critical tools for the study of craniofacial developmental abnormalities. However, there is a lack of detailed normative data of mouse craniofacial skeletal development in the literature. In this report, we employed high-resolution micro-computed tomography (μCT) in combination with morphometric measurements to analyze the postnatal craniofacial skeletal development from day 7 (P7) through day 390 (P390) of female C57BL/6NCrl mice, a widely used mouse strain. Our data demonstrates a unique craniofacial skeletal development pattern in female C57BL/6NCrl mice, and differentiates the early vs. late craniofacial growth patterns. Additionally, our data documents the complex and differential changes in bone parameters (thickness, bone volume, bone volume/tissue volume, bone mineral density, and tissue mineral density) of various craniofacial bones with different embryonic origins and ossification mechanisms during postnatal growth, which underscores the complexity of craniofacial bone development and provides a reference standard for future quantitative analysis of craniofacial bones.
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DOI：
10.1002/ar.23353
发表时间：
2016-08
期刊：
Anatomical record (Hoboken, N.J. : 2007)
影响因子：
--
作者：
Badri MK;Zhang H;Ohyama Y;Venkitapathi S;Kamiya N;Takeda H;Ray M;Scott G;Tsuji T;Kunieda T;Mishina Y;Mochida Y
通讯作者：
Mochida Y
影响因子：
4.1
作者：
Liu, Jin;Nam, Hwa Kyung;Campbell, Cassie;Gasque, Kellen Cristina da Silva;Millan, Jose Luis;Hatch, Nan E.
通讯作者：
Hatch, Nan E.
DOI：
10.1002/ar.a.20308
发表时间：
2006-03-01
期刊：
ANATOMICAL RECORD PART A-DISCOVERIES IN MOLECULAR CELLULAR AND EVOLUTIONARY BIOLOGY
影响因子：
--
作者：
Bloom, MW;Murakami, S;Duke, PJ
通讯作者：
Duke, PJ
影响因子：
4.1
作者：
Meganck, Jeffrey A.;Kozloff, Kenneth M.;Thornton, Michael M.;Broski, Stephen M.;Goldstein, Steven A.
通讯作者：
Goldstein, Steven A.
影响因子：
2.5
作者：
Martinez-Abadias, Neus;Mitteroecker, Philipp;Parsons, Trish E.;Esparza, Mireia;Sjovold, Torstein;Rolian, Campbell;Richtsmeier, Joan T.;Hallgrimsson, Benedikt
通讯作者：
Hallgrimsson, Benedikt