Anti-plasmodium activity of angiotensin II and related synthetic peptides.
Anti-plasmodium activity of angiotensin II and related synthetic peptides.
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DOI：
10.1371/journal.pone.0003296
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发表时间：
2008-09-29
期刊：
影响因子：
3.7
通讯作者：
Capurro, Margareth Lara
中科院分区：
文献类型：
--
作者：
Maciel, Ceres;de Oliveira Junior, Vani Xavier;Fazio, Marcos Antonio;Nacif-Pimenta, Rafael;Miranda, Antonio;Pimenta, Paulo F. P.;Capurro, Margareth Lara
疟原虫是疟疾的病原体，疟疾是人类最具破坏性的虫媒寄生虫。寻找和开发治疗和预防疟疾的新药是许多研究的目标。本文研究了血管紧张素Ⅰ和Ⅱ（angI和angII）及六种合成的相关肽Vaniceres 1-6（VC 1-VC6）对鸡疟原虫（Plasmodiumgallinaceum）体内和体外发育的影响。将Ang II和VC 5注射到昆虫的胸腔中，分别使蚊子唾液腺中的感染平均强度降低了88%和76%。尽管作用机制尚未完全了解，但我们已经证明这些肽选择性地破坏鸡原卟啉单胞菌细胞膜。此外，子孢子与VC 5的体外孵育降低了寄生虫对其脊椎动物宿主的感染性。VC 5对脊椎动物没有明显的激动剂作用，这使其成为一种有希望的疟疾预防和化疗药物。
Plasmodium species are the causative agents of malaria, the most devastating insect-borne parasite of human populations. Finding and developing new drugs for malaria treatment and prevention is the goal of much research. Angiotensins I and II (ang I and ang II) and six synthetic related peptides designated Vaniceres 1-6 (VC1-VC6) were assayed in vivo and in vitro for their effects on the development of the avian parasite, Plasmodium gallinaceum. Ang II and VC5 injected into the thoraces of the insects reduced mean intensities of infection in the mosquito salivary glands by 88% and 76%, respectively. Although the mechanism(s) of action is not completely understood, we have demonstrated that these peptides disrupt selectively the P.gallinaceum cell membrane. Additionally, incubation in vitro of sporozoites with VC5 reduced the infectivity of the parasites to their vertebrate host. VC5 has no observable agonist effects on vertebrates, and this makes it a promising drug for malaria prevention and chemotherapy.
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影响因子：
4.9
作者：
Dagan, A;Efron, L;Ginsburg, H
通讯作者：
Ginsburg, H
影响因子：
2.9
作者：
Fázio, MA;Oliveira, VX;Miranda, A
通讯作者：
Miranda, A
影响因子：
--
作者：
Oliveira, VX;Fázio, MA;Miranda, A
通讯作者：
Miranda, A
影响因子：
2.1
作者：
Shahabuddin, M;Fields, I;Miller, LH
通讯作者：
Miller, LH
影响因子：
2.1
作者：
de Oliveira, Vani Xavier, Jr.;Fazio, Marcos Antonio;Miranda, Antonio
通讯作者：
Miranda, Antonio