Sex-dependent hypertension and renal changes in aged rats with altered renal development.
Sex-dependent hypertension and renal changes in aged rats with altered renal development.
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肾脏发育改变的老年大鼠的性别依赖性高血压和肾脏变化
DOI：
10.1152/ajprenal.00198.2014
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Salazar F.J.
中科院分区：
文献类型：
--
作者：
Saez F;Reverte V;Paliege A;Moreno J.M;Llinás M.T;Bachmann S;Salazar F.J.
许多研究评估了几种高血压发育规划模型中的血压（BP）和肾脏变化。本研究调查了肾脏发育改变的雄性和雌性动物老年时血压、肾血流动力学和肾脏结构受到的影响程度。它还评估了肾损伤是否与环氧合酶（COX）-2和神经元一氧化氮合酶（NOS1）表达和免疫反应性的变化有关。实验在 10-11 月龄和 16-17 月龄的大鼠中进行，在肾发生期用媒介物或 ANG II 1 型受体拮抗剂 (ARAnp) 治疗。在 ARAnp 治疗的两性大鼠中均发现血压进行性升高和肾血流动力学恶化，其中雄性大鼠的这些变化更大（P<0.05）。 ARAnp治疗组雄性大鼠(74%)最大年龄时肾小球滤过率的下降幅度大于雌性大鼠(32%)(P<0.05)。光学和电子显微镜实验证明了肾脏结构的性别依赖性恶化。 ARAnp 治疗的雄性大鼠致密斑中 COX-2 和 NOS1 免疫反应性增强，但雌性大鼠未见增强。本研究报告的新发现表明，在肾脏发育过程中诱导 ANG II 效应降低的刺激会导致男女老年时血压逐渐升高和肾损伤，但男性的血压和肾脏变化比女性更大。肾损伤与男性致密斑中 COX-2 和 NOS1 的增加有关，但与肾脏发育改变的女性无关。
Numerous studies have evaluated blood pressure (BP) and renal changes in several models of developmental programming of hypertension. The present study examined to what extent BP, renal hemodynamic, and renal structure are affected at an old age in male and female animals with altered renal development. It also evaluated whether renal damage is associated with changes in cyclooxygenase (COX)-2 and neuronal nitric oxide synthase (NOS1) expression and immunoreactivity. Experiments were carried out in rats at 10–11 and 16–17 mo of age treated with vehicle or an ANG II type 1 receptor antagonist during the nephrogenic period (ARAnp). A progressive increment in BP and a deterioration of renal hemodynamics were found in both sexes of ARAnp-treated rats, with these changes being greater (P< 0.05) in male rats. The decrease in glomerular filtration rate at the oldest age was greater (P< 0.05) in male (74%) than female (32%) ARAnp-treated rats. Sex-dependent deterioration of renal structure was demonstrated in optical and electron microscopic experiments. COX-2 and NOS1 immunoreactivity were enhanced in the macula densa of male but not female ARAnp-treated rats. The present study reports novel findings suggesting that stimuli that induce a decrease of ANG II effects during renal development lead to a progressive increment in BP and renal damage at an old age in both sexes, but these BP and renal changes are greater in males than in females. The renal damage is associated with an increase of COX-2 and NOS1 in the macula densa of males but not females with altered renal development.
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肾单位数量减少大鼠的年龄和钠敏感性高血压和性别依赖性肾脏变化
影响因子：
8.3
作者：
F. Salazar;V. Reverte;Fara Saez;A. Loria;M. T. Llinás;F. Salazar;Javier Salazar
通讯作者：
Javier Salazar
低剂量一氧化氮合酶抑制小鼠模型中肾小管间质疾病的惰性过程。
DOI：
10.1152/ajprenal.00071.2008
发表时间：
2008
期刊：
American journal of physiology. Renal physiology
影响因子：
--
作者：
Stoessel,Adelina;Paliege,Alexander;Theilig,Franziska;Addabbo,Francesco;Ratliff,Brian;Waschke,Jens;Patschan,Daniel;Goligorsky,MichaelS;Bachmann,Sebastian
通讯作者：
Bachmann,Sebastian
DOI：
10.1152/ajpregu.00725.2006
发表时间：
2007-08-01
影响因子：
2.8
作者：
Grigore, Daniela;Ojeda, Norma B.;Alexander, Barbara T.
通讯作者：
Alexander, Barbara T.
影响因子：
19.6
作者：
Wang, JL;Cheng, HF;Harris, RC
通讯作者：
Harris, RC
DOI：
10.1152/ajprenal.00463.2012
发表时间：
2013-04-01
影响因子：
4.2
作者：
Franco, Martha;Tapia, Edilia;Rodriguez-Iturbe, Bernardo
通讯作者：
Rodriguez-Iturbe, Bernardo