Expression of BMP-7 in human gastric cancer and its clinical significance.
Expression of BMP-7 in human gastric cancer and its clinical significance.
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DOI：
10.1038/sj.bjc.6606075
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发表时间：
2011-02-15
影响因子：
8.8
通讯作者：
中科院分区：
文献类型：
--
作者：
骨形态发生蛋白-7（BMP-7）是属于转化生长因子超家族的信号分子。最近的研究已经证明了BMP-7表达在各种人类癌症中的临床影响。然而，很少有报道详细介绍这在胃癌。为探讨BMP-7阳性胃癌的临床病理特征，我们采用免疫组化方法检测了233例胃癌组织中BMP-7的表达。免疫组化显示，在人胃癌中，BMP-7表达不仅在细胞膜中，而且在癌细胞的细胞质中。骨形态发生蛋白7阳性表达129例（55%）。骨形态发生蛋白-7表达与肿瘤大小、淋巴结转移、静脉浸润及组织学类型有关（P<0.05）。骨形态发生蛋白-7的表达与患者的术后结果显著相关，尤其是在未分化组。多因素分析显示，BMP-7表达是仅次于浸润深度和淋巴结转移的独立预后因素（P<0.01）。从收集的数据，这将是适当的结论胃癌进展的可能调控自分泌或旁分泌BMP-7环。我们可以使用BMP-7表达作为胃癌肿瘤复发风险的强有力的预测因子之一。
Bone morphogenetic protein-7 (BMP-7) is a signalling molecule belonging to the transforming growth factor--superfamily. Recent studies have demonstrated the clinical impact of BMP-7 expression in various human cancers. However, there have been few reports detailing this in gastric cancer. We immunohistochemically investigated the expression of BMP-7 in 233 gastric cancer patients to disclose the clinicopathological features of BMP-7-positive gastric cancer. Immunohistochemically, in human gastric cancer, BMP-7 expression was identified in cellular membranes but also in the cytoplasm of cancer cells. Bone morphogenetic protein-7-positive expression was found in 129 of 233 patients (55%). Bone morphogenetic protein-7 expression was correlated with tumour size, nodal involvement, lymphatic invasion, venous invasion and histology (P<0.05). Bone morphogenetic protein-7 expression was significantly correlated with patient postoperative outcome, especially in the undifferentiated group. Multivariate analysis revealed BMP-7 expression as one of the independent prognostic factors next to the depth of invasion and nodal involvement (P<0.01). From the data collected, it would be appropriate to conclude on the possible regulation of gastric cancer progression by autocrine or paracrine BMP-7 loops. We can use BMP-7 expression as one of the strong predictors of risk of tumour recurrence in gastric cancer.
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