Bone density and size in ambulatory children with cerebral palsy.
Bone density and size in ambulatory children with cerebral palsy.
复制标题
脑瘫步行儿童的骨密度和大小。
DOI：
10.1111/j.1469-8749.2010.03852.x
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发表时间：
2011-02
影响因子：
3.8
通讯作者：
Gilsanz V
中科院分区：
文献类型：
--
作者：
Al Wren T;Lee DC;Kay RM;Dorey FJ;Gilsanz V
目的探讨脑性瘫痪（CP）患儿的轴、尾骨特性与功能（大运动功能分类系统[GMFCS]）水平的关系。比较37例CP患儿（GMFCSⅰ级12例，ⅱ级5例，ⅲ级18例，ⅳ级2例；偏瘫5例，双瘫23例，三瘫2例，四肢瘫7例；平均年龄9y 4mo， SD 1y 6mo；男性18例，女性19例）和对照组37例患儿（年龄和性别分布相同）的计算机断层定量测量结果。线性回归用于评估体积松质骨密度（vBMD）和L3椎体和胫骨几何特性的差异，调整了身高、体重和性别作为协变量。由于GMFCS III级和IV级的椎体尺寸较小，对照组的椎骨比CP组大（p=0.02），但椎体vBMD差异无统计学意义（p=0.49）。胫骨骨体积密度（p=0.09）和骨大小（p=0.02）随GMFCS水平的升高而降低。GMFCS水平对雌性骨大小的影响大于雄性（p<0.07）。患有各种程度CP的儿童，其胫骨骨可能较少，而脊柱缺陷对更多儿童的影响不同。因为即使是很小的骨缺损也可能在以后的生活中表现为骨质疏松症，所以研究所有CP儿童的骨获得是很重要的。
To examine the relation of axial and appendicular bone properties in ambulatory children with cerebral palsy (CP) to functional (Gross Motor Function Classification System [GMFCS]) level. Quantitative computed tomography measurements were compared among 37 children with CP (12 children in GMFCS level I, five in level II, 18 in level III, two in level IV; five with hemiplegia, 23 with diplegia, two with triplegia, seven with quadriplegia; mean age 9y 4mo, SD 1y 6mo; 18 males, 19 females) and 37 children in a comparison group (same age and sex distributions). Linear regression was used to evaluate differences in volumetric cancellous bone density (vBMD) and geometric properties of the L3 vertebra and tibia, adjusting for height, weight, and sex as covariates. The comparison group had larger vertebrae than the children with CP (p=0.02) owing to smaller vertebral size in GMFCS levels III and IV, but there was no difference in vertebral vBMD (p=0.49). In the tibia, bone volumetric density (p=0.09) and size (p=0.02) decreased with increasing GMFCS level. GMFCS level had a greater effect on bone size in females than in males (p<0.07). Children with CP of all levels may have less bone in their tibias, whereas spine deficits differentially affect more involved children. Because even small bone deficits may manifest as osteoporosis later in life, it is important to study bone acquisition in all children with CP.
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影响因子：
1.4
作者：
Tasdemir, HA;Buyukavci, M;Karakelleoglu, C
通讯作者：
Karakelleoglu, C
DOI：
10.1097/bpo.0b013e3181efbabc
发表时间：
2010-10
期刊：
Journal of pediatric orthopedics
影响因子：
--
作者：
Wren TA;Lee DC;Hara R;Rethlefsen SA;Kay RM;Dorey FJ;Gilsanz V
通讯作者：
Gilsanz V
影响因子：
3.8
作者：
King, W;Levin, R;Heubi, JE
通讯作者：
Heubi, JE
影响因子：
3.8
作者：
Henderson, RC;Kairalla, J;Stevenson, RD
通讯作者：
Stevenson, RD
影响因子：
5
作者：
MORA, S;GOODMAN, WG;GILSANZ, V
通讯作者：
GILSANZ, V