Genetic variation in BCL2 3'-UTR was associated with lung cancer risk and prognosis in male Chinese population.
Genetic variation in BCL2 3'-UTR was associated with lung cancer risk and prognosis in male Chinese population.
复制标题
BCL2 3'-UTR 的遗传变异与中国男性人群的肺癌风险和预后相关。
DOI：
10.1371/journal.pone.0072197
复制
发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Guo H
中科院分区：
文献类型：
--
作者：
Xu P;Liu L;Wang J;Zhang K;Hong X;Deng Q;Xiang J;Zhang X;He M;Wu T;Guo H
Bcl-2是一种重要的细胞凋亡抑制剂，具有确定的致癌潜力，并且可以通过激活抗细胞凋亡细胞防御来赋予癌细胞对治疗性治疗的抗性。我们推测BCL 2基因的遗传变异可能与肺癌的易感性和预后有关。采用TaqMan技术对1017例中国男性肺癌患者和对照组进行BCL 2基因rs 2279115、rs 1801018和rs 1564483的tagSNPs分型。这些变异与肺癌的风险和242例男性晚期非小细胞肺癌（NSCLC）患者的总生存率的关系分别进行了研究。与BCL 2 3′UTR rs 1564483 GG基因型相比，rs 1564483 GA、AA和GA+AA基因型与中国男性肺癌易感性显著降低（校正OR分别为0.78、0.73和0.76，P =0.016、0.038和0.007），而rs 1564483 A等位基因与肺癌风险呈负剂量反应关系（P趋势= 0.010）。 这些影响在老年人、吸烟者和无癌症家族史的受试者中更为明显（P趋势分别为0.017、0.043和0.005）。 此外，携带BCL 2 rs 1564483 GA+AA基因型的晚期NSCLC男性患者的中位生存时间（Long-rank P = 0.036）和死亡风险（校正HR = 0.69，P = 0.027）显著长于携带rs 1564483 GG基因型的患者。 吸烟、Ⅲ A期和未手术但接受化疗或放疗的患者的这些效应更明显（校正HR分别为0.68，0.49，0.67，0.69，0.50，均P<0.05）。 BCL 2 3′UTR rs 1564483 A等位基因与中国男性晚期非小细胞肺癌的发生风险降低和生存率提高相关，这可能为识别高危人群和预测临床预后提供一种新的生物标志物。
Bcl-2 is a critical apoptosis inhibitor with established carcinogenic potential, and can confer cancer cell resistance to therapeutic treatments by activating anti-apoptotic cellular defense. We hypothesized that genetic variants of BCL2 gene may be associated with lung cancer susceptibility and prognosis. Three selected tagSNPs of BCL2 (rs2279115, rs1801018, and rs1564483) were genotyped in 1017 paired male Chinese lung cancer cases and controls by TaqMan assay. The associations of these variants with risk of lung cancer and overall survival of 242 male advanced non-small-cell lung cancer (NSCLC) patients were separately investigated. Compared with the BCL2 3′UTR rs1564483GG genotype, the rs1564483GA, AA, and GA+AA genotypes were associated with significantly decreased susceptibilities of lung cancer in male Chinese (adjusted OR = 0.78, 0.73, and 0.76, P = 0.016, 0.038, and 0.007, respectively), while rs1564483A allele has a inverse dose-response relationship with lung cancer risk (P trend = 0.010). These effects were more evident in the elders, smokers, and subjects without family history of cancer (P trend = 0.017, 0.043 and 0.005, respectively). Furthermore, advanced NSCLC males carrying BCL2 rs1564483 GA+AA genotypes had significantly longer median survival time (Long-rank P = 0.036) and decreased death risk (adjusted HR = 0.69, P = 0.027) than patients with rs1564483GG genotype. These effects were more obvious in patients with smoking, stage IIIA, and in patients without surgery but underwent chemotherapy or radiotherapy (adjusted HR = 0.68, 0.49, 0.67, 0.69, 0.50, respectively, all P<0.05). The BCL2 3′UTR rs1564483A allele was associated with a decreased lung cancer risk and better survival for advanced NSCLC in male Chinese, which may offer a novel biomarker for identifying high-risk population and predicting clinical outcomes.
登录
查看更多内容
影响因子：
11.5
作者：
Park, Yeon Hee;Sohn, Sang Kyun;Kim, Dong Hwan
通讯作者：
Kim, Dong Hwan
影响因子：
--
作者：
Ferron, PE;Bagni, I;Nenci, I
通讯作者：
Nenci, I
影响因子：
6.6
作者：
Hirata, Hiroshi;Hinoda, Yuji;Dahiya, Rajvir
通讯作者：
Dahiya, Rajvir
影响因子：
64.8
作者：
Reed, JC
通讯作者：
Reed, JC
影响因子：
2.7
作者：
Moon, Joon Ho;Sohn, Sang Kyun;Kim, Dong Hwan
通讯作者：
Kim, Dong Hwan