Racial disparities in cancer-associated thrombosis.
Racial disparities in cancer-associated thrombosis.
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DOI：
10.1182/bloodadvances.2021006209
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发表时间：
2022-05-24
期刊：
影响因子：
7.5
通讯作者：
Wun T
中科院分区：
文献类型：
--
作者：
Datta T;Brunson A;Mahajan A;Keegan T;Wun T
黑人/非裔美国人的发病率高于美国白人，而亚洲/太平洋岛民的发病率低于美国白人。这种差异是由肺栓塞的发生率造成的。在基于人群的研究中，种族和民族与静脉血栓栓塞的风险相关。黑人/非裔美国人发病率较高，而亚洲人/太平洋岛民和西班牙裔与非西班牙裔白人相比，静脉血栓栓塞的发病率较低。癌症相关血栓（CAT）是恶性肿瘤患者的一种常见并发症，种族/民族对其发病率的影响尚未得到很好的界定。使用与加州患者出院数据集和急诊科利用数据库相关的加州癌症登记处，我们研究了2005年至2017年期间13种最常见的原发性恶性肿瘤的大型多样化患者队列（n = 942 109），以确定种族/民族与发病率和复发性CAT之间的关系。采用多变量Cox比例风险回归模型来确定种族/民族对总体CAT、特定地点CAT和复发CAT风险的影响。除骨髓瘤外，黑人/非裔美国人在所有肿瘤类型中都有较高的CAT发病率，而在调整了潜在的混杂因素后，亚洲/太平洋岛民与非西班牙裔白人相比，CAT的发病率一直较低。造成种族/民族差异的主要原因是肺栓塞的发生率。我们推测种族/民族与CAT发病率的关联可能部分是因为潜在的血栓易感性因祖先而异，但我们也必须考虑健康的社会决定因素对我们结果的影响。
Blacks/African Americans have a higher incidence, whereas Asians/Pacific Islanders have a lower incidence, of CAT than White Americans. The disparity is driven by the incidence of pulmonary embolism. Race and ethnicity are associated with risk of venous thromboembolism in population-based studies. Blacks/African Americans have a higher incidence, whereas Asians/Pacific Islanders and Hispanics have a lower incidence of venous thromboembolism compared with non-Hispanic Whites. The impact of race/ethnicity on the incidence of cancer-associated thrombosis (CAT), a common complication in patients with malignancy, has not been well defined. Using the California Cancer Registry linked to the California Patient Discharge Dataset and Emergency Department Utilization database, we studied a large, diverse cohort of patients (n = 942 109) from 2005 to 2017 with the 13 most common, first primary malignancies to determine the association between race/ethnicity and incidence of incident and recurrent CAT. Multivariable Cox proportional hazards regression models were performed to determine the effect of race/ethnicity on the risk of overall CAT, specific CAT by location, and recurrent CAT. Blacks/African Americans had a higher incidence of CAT for all tumor types except myeloma, whereas Asians/Pacific Islanders had a consistently lower incidence of CAT compared with non-Hispanic Whites, after adjusting for potential confounders. The main driver for the racial/ethnic differences was incidence of pulmonary embolism. We speculate the association of race/ethnicity with incidence of CAT may be partially because of underlying thrombotic predisposition that varies by ancestry, but we also must consider the impact of social determinants of health on our results.
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影响因子：
45.3
作者：
Key, Nigel S.;Khorana, Alok A.;Falanga, Anna
通讯作者：
Falanga, Anna
DOI：
10.4137/cmo.s18991
发表时间：
2014
期刊：
Clinical Medicine Insights. Oncology
影响因子：
--
作者：
Elyamany G;Alzahrani AM;Bukhary E
通讯作者：
Bukhary E
影响因子：
4.6
作者：
Lee E;Kang SB;Choi SI;Chun EJ;Kim MJ;Kim DW;Oh HK;Ihn MH;Kim JW;Bang SM;Lee JO;Kim YJ;Kim JH;Lee JS;Lee KW
通讯作者：
Lee KW
影响因子：
12.8
作者：
Heit, John A.;Beckman, Michele G.;Philipp, Claire S.
通讯作者：
Philipp, Claire S.
影响因子：
37.8
作者：
Lee, AYY;Levine, MN
通讯作者：
Levine, MN