Somatostatin receptor imaging with [68Ga]Ga-DOTATATE positron emission tomography/computed tomography (PET/CT) in patients with nasopharyngeal carcinoma
Somatostatin receptor imaging with [68Ga]Ga-DOTATATE positron emission tomography/computed tomography (PET/CT) in patients with nasopharyngeal carcinoma
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鼻咽癌患者使用 [68Ga]Ga-DOTATATE 正电子发射断层扫描/计算机断层扫描 (PET/CT) 进行生长抑素受体成像
DOI：
10.1007/s00259-021-05587-7
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发表时间：
2021-10
影响因子：
9.1
通讯作者：
Haojun Chen
中科院分区：
文献类型：
--
作者：
Liang Zhao;Yizhen Pang;Yuhuan Wang;Jianhao Chen;Yanzhen Zhuang;Jingjing Zhang;Long Zhao;Long Sun;Hua Wu;Xiaoyuan Chen;Qin Lin;Haojun Chen
目的探讨[68Ga]Ga-DOTATATE正电子发射断层扫描/计算机断层扫描（PET/CT）在非角化鼻咽癌（NPC）患者中的可行性，并评价[68Ga]Ga-DOTATATE PET/CT是否可用于鼻咽癌中生长抑素受体2 （SSTR2）的无创检测。方法本前瞻性研究纳入了2021年2月至5月期间接受[68Ga]Ga-DOTATATE PET/CT检查的鼻咽癌患者。计算比较原发性和转移性鼻咽癌病变中[68Ga]Ga-DOTATATE和[18F]FDG的摄取量，并分析SSTR2评分组间[68Ga]Ga-DOTATATE的摄取量。结果共纳入36例患者，其中初分期25例，复发率11例；33例患者还接受了[18F]FDG PET/CT进行分期/再分期，作为常规诊断工作的一部分。[68Ga]Ga-DOTATATE PET/CT显示原发性和转移性鼻咽癌病变有强烈的示踪剂摄取。[68Ga]Ga-DOTATATE对原发性NPC病变的示踪剂摄取高于[18F]FDG PET (SUVmax: 12.03vs.10.07，P= 0.048；0.86，P< 0.001)和区域淋巴结转移（中位SUVmax: 9.11vs.6.12， P< 0.001），在骨和内脏转移中也具有可比性。重要的是，大多数鼻咽癌病变显示强烈的SSTR2表达（85.7%），这与[68Ga]Ga-DOTATATE摄取密切相关。sstr2阴性病变的SUVmax明显低于sstr2阳性病变（SUVmax: 4.95vs）。12.61, P = 0.013)。结论[68Ga]Ga-DOTATATE PET/CT与[18F]FDG PET/CT相比，具有良好的图像对比度和相当的诊断效果，是一种很有前途的原发性和转移性鼻咽癌的成像方式。在大多数npc中观察到强烈的SSTR2表达，这种表达与[68Ga]Ga-DOTATATE摄取显著相关。
PurposeTo explore the feasibility of [68Ga]Ga-DOTATATE positron emission tomography/computed tomography (PET/CT) in patients with non-keratinizing nasopharyngeal carcinoma (NPC) and to evaluate whether [68Ga]Ga-DOTATATE PET/CT could be used for non-invasive determination of somatostatin receptor 2 (SSTR2) expression in NPC.MethodsThis prospective study included patients with NPC who underwent [68Ga]Ga-DOTATATE PET/CT between February and May 2021. The [68Ga]Ga-DOTATATE and [18F]FDG uptakes in primary and metastatic NPC lesions were calculated and compared, and the [68Ga]Ga-DOTATATE uptake between SSTR2 score groups was analysed.ResultsA total of 36 participants (25 patients, initial staging; 11 patients, recurrence detection) were included; 33 patients also underwent [18F]FDG PET/CT for staging/restaging as a part of their routine diagnostic workup. [68Ga]Ga-DOTATATE PET/CT showed an intense tracer uptake in primary and metastatic NPC lesions. The radiotracer uptake was higher with [68Ga]Ga-DOTATATE than with [18F]FDG PET in primary NPC lesions (SUVmax: 12.03vs.10.07,P= 0.048; tumour-to-brain ratio: 36.16vs. 0.86,P< 0.001) and regional lymph node metastases (median SUVmax: 9.11vs.6.12, P < 0.001) and comparable in bone and visceral metastases. Importantly, most NPC lesions showed intense SSTR2 expression (85.7%), which was strongly correlated with the [68Ga]Ga-DOTATATE uptake. The SUVmax of SSTR2-negative lesions was significantly lower than that of SSTR2-positive lesions (SUVmax: 4.95vs. 12.61,P= 0.013).Conclusion[68Ga]Ga-DOTATATE PET/CT is a promising imaging modality for detecting primary and metastatic NPC, with favourable image contrast and comparable diagnostic efficacy when compared to [18F]FDG PET/CT. An intense SSTR2 expression was observed in most NPCs, and this expression was significantly correlated with the [68Ga]Ga-DOTATATE uptake.
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影响因子：
16.6
作者：
Lechner M;Schartinger VH;Steele CD;Nei WL;Ooft ML;Schreiber LM;Pipinikas CP;Chung GT;Chan YY;Wu F;To KF;Tsang CM;Pearce W;Morelli D;Philpott M;Masterson L;Nibhani R;Wells G;Bell CG;Koller J;Delecluse S;Yip YL;Liu J;Forde CT;Forster MD;Jay A;Dudás J;Krapp A;Wan S;Uprimny C;Sprung S;Haybaeck J;Fenton TR;Chester K;Thirlwell C;Royle G;Marafioti T;Gupta R;Indrasari SR;Herdini C;Slim MAM;Indrawati I;Sutton L;Fles R;Tan B;Yeong J;Jain A;Han S;Wang H;Loke KSH;He W;Xu R;Jin H;Cheng Z;Howard D;Hwang PH;Le QT;Tay JK;West RB;Tsao SW;Meyer T;Riechelmann H;Oppermann U;Delecluse HJ;Willems SM;Chua MLK;Busson P;Lo KW;Wollmann G;Pillay N;Vanhaesebroeck B;Lund VJ
通讯作者：
Lund VJ
DOI：
10.1007/s00259-009-1080-6
发表时间：
2009
影响因子：
9.1
作者：
S. Ng;Sheng-Chieh Chan;T. Yen;J. Chang;C. Liao;S. Ko;Feng-Yuan Liu;S. Chin;K. Fan;Cheng‐Lung Hsu
通讯作者：
S. Ng;Sheng-Chieh Chan;T. Yen;J. Chang;C. Liao;S. Ko;Feng-Yuan Liu;S. Chin;K. Fan;Cheng‐Lung Hsu
DOI：
10.1016/b978-0-12-814936-2.00002-x
发表时间：
2019
期刊：
Nasopharyngeal Carcinoma
影响因子：
--
作者：
M. Lung;Wei Dai;J. Ko
通讯作者：
M. Lung;Wei Dai;J. Ko
影响因子：
2.1
作者：
Carle, Laura N.;Ko, Charles C.;Castle, James T.
通讯作者：
Castle, James T.
影响因子：
3.3
作者：
Chong, V. F. H.;Ong, C. K.
通讯作者：
Ong, C. K.