Effects of 3-h hypothermia after neonatal hyperthermic hypoxic-ischemic encephalopathy in rat models on behavioral prognosis and anatomical and histological features after growth
Effects of 3-h hypothermia after neonatal hyperthermic hypoxic-ischemic encephalopathy in rat models on behavioral prognosis and anatomical and histological features after growth
复制标题
新生儿高温缺氧缺血性脑病模型大鼠低温3 h对行为预后及生长后解剖组织学特征的影响
DOI：
10.3109/14767058.2015.1103223
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
T. Hosono
中科院分区：
文献类型：
--
作者：
Y. Nishimura;T. Hosono
摘要目的：采用新生大鼠高温性缺氧缺血性脑病(HIE)模型，探讨3h低温对新生大鼠生长后学习能力和运动功能的影响。方法：将大鼠分为3组：N组(新生大鼠高温HIE后不再低温3h)、H组(新生大鼠高温HIE后再低温3h)和假手术组(S)。采用转杆试验和跳台被动回避试验对其故障进行评估。并对受损侧大脑宽度和海马CA1区面积进行了分析。结果：在转杆试验中，N组的成绩明显差于S组。跳台被动回避实验中，N组成绩明显差于S组和H组。N组受损侧大脑最大宽度和海马CA1区面积均明显小于S组和H组。结论：新生儿高温性缺氧缺血性损伤限制了新生儿出生后的运动功能和学习能力，缺氧缺血性脑病后3h低温可明显改善这种神经功能障碍。
Abstract Objective: To clarify the effects of 3-h hypothermia on learning ability and motor function after growth, employing neonatal rat models with hyperthermic hypoxic-ischemic encephalopathy (HIE). Methods: We divided all rats into three groups: N (adult rats after neonatal hyperthermic HIE without subsequent 3-h hypothermia), H (adult rats after neonatal hyperthermic HIE with subsequent 3-h hypothermia) and Sham (S) groups. We evaluated their malfunctions with the rota-rod test and the step-down passive avoidance test. We also analyzed the cerebrum width and the hippocampal CA1 area of the insulted hemisphere. Results: In the rota-rod test, the result of the N group was significantly worse than that of the S group. In the step-down passive avoidance test, the result of the N group was significantly worse than those of the S and H groups. The longest cerebrum width and the hippocampal CA1 area of the insulted hemisphere of the N group were significantly smaller than those of the S and H groups. Conclusion: Neonatal hyperthermic hypoxic-ischemic insult restricts motor function and learning ability after growth, and such neuronal malfunctions can be relieved by hypothermia for 3 h soon after neonatal HIE.
DOI：
10.1159/000244036
发表时间：
1994
期刊：
Biology of the neonate
影响因子：
--
作者：
J. Towfighi;C. Housman;R. Vannucci;D. Heitjan
通讯作者：
J. Towfighi;C. Housman;R. Vannucci;D. Heitjan