Capturing the value in printed pharmaceuticals - A study of inkjet droplets released from a polymer matrix.
Capturing the value in printed pharmaceuticals - A study of inkjet droplets released from a polymer matrix.
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捕捉印刷药品的价值 - 对聚合物基质释放的喷墨液滴的研究。
DOI：
10.1016/j.ijpharm.2021.120436
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发表时间：
2021
影响因子：
5.8
通讯作者：
Zhang Q
中科院分区：
文献类型：
--
作者：
Zhang Q
个性化组合剂量的未来将依赖于将多个单独的API、其载体流体和赋形剂编程和递送到稳定的基质中，其中每一个将保持分离，直到需要释放。最近的技术已经展示了如何使用喷墨打印从聚合物基质打印、捕获和释放材料，喷墨打印是一种低成本和可定制的技术。制剂的液滴被递送到流体聚合物基质，在那里它们被吸入并保持固定在上表面下方，通过界面能的平衡保持在适当位置。一旦周围的基质固化和凝固，涂层或基质就捕获了制剂，但是每个液滴具有通向外部的小开口或孔，这将允许通过扩散递送。然而，虽然已经详细探讨了捕获机制，但迄今为止，从未研究过这种交付所涉及的释放或将其量化到同一水平。在这里，我们展示了第一项研究，以量化从聚合物基质中释放的模型系统。递送并捕获荧光素水溶液，释放到琼脂糖凝胶和水性环境中。这项工作表明，界面张力的平衡防止可靠的释放，直到低浓度的表面活性剂。这为进一步探索使用数字控制和负担得起的技术在一种材料中稳定药物组合提供了一条途径。
The future of personalised combination dosages will rely on the programming and delivery of multiple, separate APIs, their carrier fluids and excipients to a stable matrix, where each will remain separate until it is needed to be released. A recent technique has demonstrated how to print, capture and release materials from a polymer matrix using inkjet printing, a low cost and customisable technique. Droplets of a formulation are delivered to a fluid polymer matrix, where they are imbibed and remain pinned just under the upper surface, held in place by a balance of interfacial energies. Once the surrounding matrix cures and solidifies, the coating or matrix has trapped the formulation, but each drop has a small opening or pore to the outside that will allow delivery through diffusion. However, while the trapping mechanism has been explored in detail, to-date the release involved in this delivery has never been studied or quantified to the same level. Here we show a first study to quantify the release of a model system from a polymer matrix. An aqueous fluorescein solution is delivered and trapped, with release demonstrated to an agarose gel and aqueous environments. The work reveals that the balance of interfacial tensions prevents a reliable release until low concentrations of surfactant are included. This provides a route forward to further explore stabilising combinations of drugs within one material using a digitally controlled and affordable technique.
使用热喷墨打印华法林治疗的个性化
影响因子：
4.6
作者：
P. R. Vuddanda;M. Alomari;Cornelius C. Dodoo;Sarah J Trenfield;S. Velaga;A. Basit;S. Gaisford
通讯作者：
S. Gaisford
DOI：
10.1021/la302420s
发表时间：
2012
期刊：
Langmuir : the ACS journal of surfaces and colloids
影响因子：
--
作者：
Rónán Daly;J. Sader;J. Boland
通讯作者：
J. Boland
影响因子：
3.7
作者：
Buanz, Asma B. M.;Saunders, Mark H.;Gaisford, Simon
通讯作者：
Gaisford, Simon