Body Composition Measures and N-terminal pro-B-type Natriuretic Peptide (NT-pro-BNP) in US Adults.
Body Composition Measures and N-terminal pro-B-type Natriuretic Peptide (NT-pro-BNP) in US Adults.
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DOI：
10.1093/clinchem/hvad085
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发表时间：
2023-08-02
影响因子：
9.3
通讯作者：
中科院分区：
文献类型：
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n端前b型利钠肽（NT-pro-BNP）与双能x线吸收仪（DEXA）衍生的体重和成分测量的关系在很大程度上是未知的。我们纳入了1999-2004年全国健康与营养调查中年龄≥20岁的参与者，并测量了NT-pro-BNP和dexa衍生的身体成分（脂肪和瘦肉质量）。我们使用线性和逻辑回归来表征身体质量和组成（身体质量指数[BMI]、腰围[WC]、脂肪质量和瘦质量）与NT-pro-BNP之间的关系，并调整心血管危险因素。我们对9134名无心血管疾病的成年人进行了性别特异性分析（平均年龄44.4岁，50.8%为女性，72%为白人成年人）。调整后的NT-proBNP均值在BMI、WC、脂肪质量和瘦质量最高的四分位数中最低。在dexa来源的瘦质量的最高和最低四分位数之间，NT-pro-BNP的调整后绝对差异很大，男性为- 6.26 pg/mL(95%可信区间[CI]， - 8.99至- 3.52)，女性为- 22.96 pg/mL （95% CI, - 26.83至- 19.09）。瘦体重与NT-pro-BNP升高≥81.4 pg/mL（最高四分位数）呈强烈的负相关——男性的优势比（OR）为0.58 (95% CI, 0.39-0.86)，女性的优势比（OR）为0.59 （95% CI, 0.47-0.73）。进一步调整脂肪量、BMI或WC并没有明显改变瘦体重与nt -亲bnp的负相关关系。在美国成年人的全国样本中，瘦体重与NT-pro-BNP呈负相关。
The associations of N-terminal pro-B-type natriuretic peptide (NT-pro-BNP) with dual energy x-ray absorptiometry (DEXA)-derived measures of body mass and composition are largely unknown. We included participants aged ≥20 years from the 1999–2004 National Health and Nutrition Examination Survey with NT-pro-BNP and DEXA-derived body composition (fat and lean mass) measures. We used linear and logistic regression to characterize the associations of measures of body mass and composition (body mass index [BMI], waist circumference [WC], fat mass, and lean mass) with NT-pro-BNP, adjusting for cardiovascular risk factors. We conducted sex-specific analyses among 9134 adults without cardiovascular disease (mean age 44.4 years, 50.8% women, and 72% White adults). The adjusted mean NT-proBNP values were lowest in the highest quartiles of BMI, WC, fat mass, and lean mass. There were large adjusted absolute differences in NT-pro-BNP between the highest and lowest quartiles of DEXA-derived lean mass, −6.26 pg/mL (95% confidence interval [CI], −8.99 to −3.52) among men and −22.96 pg/mL (95% CI, −26.83 to −19.09) among women. Lean mass exhibited a strong inverse association with elevated NT-pro-BNP ≥ 81.4 pg/mL (highest quartile) - odds ratio (OR) 0.58 (95% CI, 0.39–0.86) in men and OR 0.59 (95% CI, 0.47–0.73) in women for highest lean mass quartile vs. lowest quartile. Further adjustment for fat mass, BMI, or WC did not appreciably alter the inverse association of lean mass with NT-pro-BNP. In a national sample of US adults, lean mass was inversely associated with NT-pro-BNP.
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DOI：
10.1253/circj.cj-15-0589
发表时间：
2015
期刊：
Circulation journal : official journal of the Japanese Circulation Society
影响因子：
--
作者：
Gupta DK;Wang TJ
通讯作者：
Wang TJ
影响因子：
2.8
作者：
Cheng, Susan;Fox, Caroline S.;Wang, Thomas J.
通讯作者：
Wang, Thomas J.
影响因子：
7.7
作者：
Miyashita K;Itoh H;Tsujimoto H;Tamura N;Fukunaga Y;Sone M;Yamahara K;Taura D;Inuzuka M;Sonoyama T;Nakao K
通讯作者：
Nakao K
影响因子：
9.3
作者：
Parrinello, Christina M.;Grams, Morgan E.;Coresh, Josef
通讯作者：
Coresh, Josef
影响因子：
37.8
作者：
Das, SR;Drazner, MH;de Lemos, JA
通讯作者：
de Lemos, JA