Infection with Hymenolepis diminuta is more effective than daily corticosteroids in blocking chemically induced colitis in mice.
Infection with Hymenolepis diminuta is more effective than daily corticosteroids in blocking chemically induced colitis in mice.
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DOI：
10.1155/2010/384523
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发表时间：
2010
影响因子：
--
通讯作者：
McKay DM
中科院分区：
文献类型：
--
作者：
Melon A;Wang A;Phan V;McKay DM
目的.比较感染绦虫、缩小膜壳绦虫和给予类固醇（地塞米松）对二硝基苯磺酸（DNBS-）诱导的小鼠结肠炎的抑制作用。程序.小鼠用DNBS处理，感染H.或每日用地塞米松（2 mg/Kg，ip.）并在DNBS后72小时通过计算疾病活动性和组织学损伤评分以及脾细胞细胞因子产生来评估。结果H.与其他组相比，缺陷型感染的小鼠显示脾细胞产生的IL-4和IL-10增加，并保护其免受DNBS诱导的结肠炎。相比之下，地塞米松在结肠炎治疗中几乎没有益处。各组之间结肠中的胶原蛋白沉积没有差异。结论. H. diminuta在预防DNBS诱导的结肠炎方面上级地塞米松并且没有导致额外的副作用（即，胶原沉积）。如果“蠕虫疗法”要成为肠道或其他组织中特定炎症性疾病的可行治疗方法，与当前治疗方法的比较和长期随访研究是必不可少的。
Purpose. To compare infection with the tapeworm, Hymenolepis diminuta, with steroid (dexamethasone) administration in the inhibition of dinitrobenzene sulfonic acid- (DNBS-) induced colitis in mice. Procedures. Mice were treated with DNBS ± infected with H. diminuta or treated with daily dexamethasone (2 mg/Kg, ip.) and were assessed 72 hours post-DNBS by the calculation of disease activity and histological damage scores, and spleen cell cytokine production. Results. H. diminuta-infected mice showed increased IL-4 and IL-10 production by spleen cells compared to other groups and were protected from DNBS-induced colitis. In contrast, there was little benefit of dexamethasone in the treatment of colitis. Collagen deposition in the colon was not different between the groups. Conclusions. H. diminuta was superior to dexamethasone in the prevention of DNBS-induced colitis and did not result in additional side effects (i.e., collagen deposition). Comparisons with current therapeutics and long-term followup to studies are essential if “helminth therapy” is to become a viable treatment for specific inflammatory diseases in the gut or other tissues.
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