Absence of age-related prefrontal NAA change in adults with autism spectrum disorders.
Absence of age-related prefrontal NAA change in adults with autism spectrum disorders.
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DOI：
10.1038/tp.2012.108
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发表时间：
2012-10-23
影响因子：
6.8
通讯作者：
Yamasue H
中科院分区：
文献类型：
--
作者：
Aoki Y;Abe O;Yahata N;Kuwabara H;Natsubori T;Iwashiro N;Takano Y;Inoue H;Kawakubo Y;Gonoi W;Sasaki H;Murakami M;Katsura M;Nippashi Y;Takao H;Kunimatsu A;Matsuzaki H;Tsuchiya KJ;Kato N;Kasai K;Yamasue H
自闭症谱系障碍（ASD）的非典型脑发育轨迹已被认为是行为发展非典型过程的潜在病因。由于儿童期是神经元和突触发育成熟的时期，许多神经影像学研究都集中在儿童期来研究脑结构和功能的非典型年龄相关变化。然而，最近的研究表明，自闭症患者大脑的非典型年龄相关结构变化扩展到儿童期之后，并构成终身行为适应困难的神经基础。因此，我们使用3-T质子磁共振波谱（1H-MRS）在内侧前额叶皮层（PFC）的单体素在24名成年男性与非药物治疗的高功能ASD和25名年龄，智商和父母的社会经济背景匹配的男性与典型的发展（TD）的大脑成熟的神经化学方面的影响。多因素协方差分析显示ASD患者的N-乙酰天冬氨酸（NAA）水平显著高于TD患者（F=4.83，P=0.033）。TD组NAA水平与高龄呈显著正相关（r=-0.618，P =0.001），ASD组NAA水平与高龄无显著相关（r=0.258，P=0.223）。Fisher's r-to-z转换显示ASD和TD组之间的相关性存在显著差异（Z=-3.23，P=0.001），这表明年龄-NAA关系对TD患者具有显著特异性。目前的1H-MRS研究提供了新的证据，表明ASD个体大脑成熟的神经化学方面的非典型年龄相关变化超出了儿童期，并在成年期持续存在。
Atypical trajectory of brain growth in autism spectrum disorders (ASDs) has been recognized as a potential etiology of an atypical course of behavioral development. Numerous neuroimaging studies have focused on childhood to investigate atypical age-related change of brain structure and function, because it is a period of neuron and synapse maturation. Recent studies, however, have shown that the atypical age-related structural change of autistic brain expands beyond childhood and constitutes neural underpinnings for lifelong difficulty to behavioral adaptation. Thus, we examined effects of aging on neurochemical aspects of brain maturation using 3-T proton magnetic resonance spectroscopy (1H-MRS) with single voxel in the medial prefrontal cortex (PFC) in 24 adult men with non-medicated high-functioning ASDs and 25 age-, IQ- and parental-socioeconomic-background-matched men with typical development (TD). Multivariate analyses of covariance demonstrated significantly high N-acetylaspartate (NAA) level in the ASD subjects compared with the TD subjects (F=4.83, P=0.033). The low NAA level showed a significant positive correlation with advanced age in the TD group (r=−0.618, P=0.001), but was not evident among the ASD individuals (r=0.258, P=0.223). Fisher's r-to-z transformation showed a significant difference in the correlations between the ASD and TD groups (Z=−3.23, P=0.001), which indicated that the age–NAA relationship was significantly specific to people with TD. The current 1H-MRS study provided new evidence that atypical age-related change of neurochemical aspects of brain maturation in ASD individuals expands beyond childhood and persists during adulthood.
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DOI：
10.1126/science.1201940
发表时间：
2011-08-26
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Green DR;Galluzzi L;Kroemer G
通讯作者：
Kroemer G
影响因子：
3.9
作者：
Esbensen, Anna J.;Seltzer, Marsha Mailick;Bodfish, James W.
通讯作者：
Bodfish, James W.
影响因子：
3.3
作者：
Gruber, S.;Pinker, K.;Moser, E.
通讯作者：
Moser, E.
影响因子：
5.7
作者：
Carper, RA;Moses, P;Courchesne, E
通讯作者：
Courchesne, E
影响因子：
10.6
作者：
Carper, RA;Courchesne, E
通讯作者：
Courchesne, E