Monosynaptic excitation of medullary inspiratory neurons by bulbospinal inspiratory neurons of the ventral respiratory group in the cat
Monosynaptic excitation of medullary inspiratory neurons by bulbospinal inspiratory neurons of the ventral respiratory group in the cat
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猫腹侧呼吸群球脊髓吸气神经元对延髓吸气神经元的单突触兴奋
DOI：
10.1007/bf00247352
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发表时间：
2004
影响因子：
2
通讯作者：
M. Manabe
中科院分区：
文献类型：
--
作者：
K. Ezure;M. Manabe
在麻醉、制动和人工通气的猫上，我们研究了腹侧呼吸组（VRG）球脊髓吸气（BS-I）神经元的延髓侧支的连接。将投射到对侧脊髓的BS-Ⅰ神经元细胞外分离，并从对侧VRG的呼吸神经元进行细胞内记录。使用BS-1神经元的细胞外尖峰作为触发器（尖峰触发平均法）来平均细胞内膜电位。快速上升和短暂的去极化电位锁定的触发棘波，并被证明是单一的EPSPs引起的单突触的延髓侧支的BS-I神经元。共分析了137对，在11对中发现了单一的EPSP。4个BS-I神经元和7个吸气迷走运动神经元接受来自BS-I神经元延髓侧支的EPSP。这些结果表明：1）VRG内的BS-Ⅰ神经元同时驱动延髓副呼吸肌运动神经元和膈或肋间运动神经元; 2）两侧的BS-Ⅰ神经元通过兴奋性联系实现同步化; 3）BS-Ⅰ神经元的增强放电模式可能部分由BS-Ⅰ神经元群体内的这种再兴奋性联系产生。
SummaryIn Nembutal-anesthetized, immobilized, and artificially ventilated cats, we studied the connectivity of medullary collaterals of bulbospinal inspiratory (BS-I) neurons in the ventral respiratory group (VRG). BS-I neurons which projected to the contralateral spinal cord were isolated extracellularly and intracellular recordings were made from the respiratory neurons in the contralateral VRG. The intracellular membrane potentials were averaged using extracellular spikes of the BS-I neurons as triggers (spike-triggered averaging method). Fast-rising and short-lasting depolarizing potentials locked to the triggering spikes were obtained and shown to be unitary EPSPs induced monosynaptically by the medullary collaterals of BS-I neurons. A total of 137 pairs were analyzed and unitary EPSPs were found in 11 pairs. Four BS-I neurons and 7 inspiratory vagal motoneurons received EPSPs from the medullary collaterals of BS-I neurons. These findings suggest that 1) BS-I neurons in the VRG drive medullary motoneurons of accessory respiratory muscles and phrenic or intercostal motoneurons simultaneously, 2) BS-I neurons on both sides synchronize via the excitatory connections, and 3) the augmenting firing pattern of BS-I neurons might partly be produced by this reexcitatory connection within the population of BS-I neurons.
同时监测的猫侧髓呼吸神经元之间的功能关联。
影响因子：
2.5
作者：
Segers,LS;Shannon,R;Saporta,S;Lindsey,BG
通讯作者：
Lindsey,BG
猫髓质背侧和腹侧呼吸群吸气神经元之间的相互作用。
影响因子：
2.5
作者：
Feldman,JL;Speck,DF
通讯作者：
Speck,DF