Acupoint catgut embedding improves learning and memory impairment in vascular dementia rats.
Acupoint catgut embedding improves learning and memory impairment in vascular dementia rats.
复制标题
穴位埋线改善血管性痴呆大鼠学习记忆障碍。
DOI：
10.21037/atm-22-6402
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发表时间：
2023-01-31
影响因子：
--
通讯作者：
Tang, Zhong-Sheng
中科院分区：
文献类型：
--
作者：
Zhu, Shi-Jie;Li, Xia;Wei, Yu-Wei;Luo, Ya-Fei;Tang, Gui-Hua;Tang, Zhong-Sheng
Vascular dementia (VD) is a disease that affects brain function through cerebrovascular disease. Due to its complex pathogenesis, there is no effective drug treatment for VD. The present study aimed to evaluate the role of acupoint catgut embedding in the treatment of rats with VD and its possible molecular mechanism. A modified 4 vessel occlusion (4-VO) method was used to establish a VD model rat, and spatial learning and memory ability was assessed using the Morris water maze (MWM) test. The protein expression levels were detected by Western blot. Hematoxylin and eosin (HE) staining was used for histological analysis and enzyme-linked immunosorbent assay (ELISA) was applied for analysis of serum inflammatory factors. We successfully constructed VD model rats with spatial learning and memory impairment, hippocampus injury, and high inflammatory response. Treatment of VD rats with acupoint catgut embedding significantly reduced escape latency and increased the time in the target quadrant and platform crossing times. VD-mediated hippocampal tissue damage and inflammatory reaction [down-regulating interleukin-1β (IL-1β), interleukin-6 (IL-6)] were significantly alleviated by acupoint catgut embedding treatment. In addition, further mechanism exploration found that acupoint catgut embedding treatment could improve the activity of the toll-like receptor 4 (TLR4)/myeloid differentiation factor 88 (MyD88)/nuclear factor-κB (NF-κB) signaling pathway. In summary, acupoint catgut embedding treatment improved spatial learning and memory loss, alleviated pathological damage of the hippocampus, and inhibited inflammation response in VD rats, which was probably related to the inhibition of the TLR4/MyD88/NF-κB signaling pathway. Acupoint catgut embedding may warrant further study as an adjuvant therapy for the treatment of VD.
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影响因子：
3.1
作者：
Shen F;Wang J;Gao F;Wang J;Zhu G
通讯作者：
Zhu G
影响因子：
5.6
作者：
Song D;Jiang X;Liu Y;Sun Y;Cao S;Zhang Z
通讯作者：
Zhang Z
影响因子：
5.7
作者：
通讯作者：
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DOI：
10.13702/j.1000-0607.170282
发表时间：
2018-01-25
期刊：
Zhen ci yan jiu = Acupuncture research
影响因子：
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作者：
Chen, Pan-Bi;Chen, Jing;Yang, Xiao-Fang
通讯作者：
Yang, Xiao-Fang
影响因子：
--
作者：
Wang, Lu;Yang, Jing-Wen;Liu, Cun-Zhi
通讯作者：
Liu, Cun-Zhi